No abstract

A physical basis for reductionism is put forth in the form of five propositions that bridge levels of organization in natural phenomena. The outlook is that complex systems and processes all have to be traced back to physical law, which applies the only general scientific constraint on reality, but that out of physical law a hierarchy of organization emerges. The basic extension of normal physics in this homeokinetic field form is to complex systems. In such systems the repetitive units of concern are internally complex and exhibit elaborate internal time-delayed processes, for example, memory.

A t heoretical investigation has been made of the attenuation and lag of an oscillatory pressure variat ion applied to one end of a tube, when the other end is connected to a pressuresensitive element.An elementary theory based on incompressi ble viscous-fluid flow is first developed. The elementary solution is t hen modified to take into account compressibili ty; fi nite pressure amplitudes; appreciable fluid acceleration; and finite length of tubing (en d effects). Account is taken of heat t ran sfer into the tu be.The complete th eory is derived in an appendix. The results are summarized in eight graphs in a form convenient for use in computing the lag and attenuation of a sinusoidal oscillation in a trans mission tube.

The current concepts for the functional unit of mammalian skeletal muscle are reviewed and shown to lack components that are required for determining the unit. To secure a definition for the functional unit, requisite criteria were selected, and the manner by which these criteria were used to define the functional unit are discussed. For deriving a definition of the unit the following values were obtained: the unit is associated with the total length of the muscle fiber, which may achieve a maximum length of 60 cm; it exhibits an average diameter of 40 micrometers/fiber; it is associated with a capillary net whose length (arteriole to venule) is about 750-1,000 micrometers max; the net exhibits a capillary-to-fiber ratio for long capillaries of approximately 1-1.5:1, with a transverse capillaries occurring approximately every 150 micrometers; and it has a fiber-to-motor end plate ratio of 1:1. The correlation between anatomic data and functional data indicate that a functional unit of muscle is delimited by about 1 mm2 of the cross-sectional area of a muscle bundle, since this is the maximum area under autonomic control of its particular arteriolar blood supply, the metabolic throttle that determines the power being expended by the muscle bundle.

A scheme is outlined for a useful way to think about the complex biological organism, man. It is based on physiological findings that the regulating and control functions in the system make use of active processes, exhibiting oscillatory properties [1]. The resulting homeostatic regulation, which was the key concept proposed by Bernard, Sechenov, and Cannon for the living system [2], emerges from mediation of these oscillators. Because of its dynamic character, the scheme is renamed homeokinesis [3]. The concept may be extended to man’s behavioral complex. In outline, it touches on all the time or frequency domains in life—that is, of the many episodes in man.