We report on recent advances in the operation of bubble-assisted Liquid Hole-Multipliers (LHM). By confining a vapor bubble under or adjacent to a perforated electrode immersed in liquid xenon, we could record both radiation-induced ionization electrons and primary scintillation photons in the noble liquid. Four types of LHM electrodes were investigated: a THGEM, standard double-conical GEM, 50 µm-thick single-conical GEM (SC-GEM) and 125 µm-thick SC-GEMall coated with CsI photocathodes. The 125 µm-thick SC-GEM provided the highest electroluminescence (EL) yields, up to ~400 photons per electron over 4with an RMS pulse-height resolution reaching 5.5% for events comprising ~7000 primary electrons. Applying a high transfer field across the bubble, the EL yield was further increased by a factor of ~5. The feasibility of a vertical-mode LHM, with the bubble confined between two vertical electrodes, and the operation of a two-stage LHM configuration were demonstrated for the first time. We combine electrostatic simulations with observed signals to draw conclusions regarding the location of the liquid-gas interface and suggest an explanation for the observed differences in EL yield between the investigated electrodes.
Background: Diffusing alpha-emitters Radiation Therapy ("DaRT") is a new method, presently in clinical trials, which allows treating solid tumors by alpha particles.DaRT relies on interstitial seeds carrying 𝜇Ci-level 224 Ra activity below their surface, which release a chain of short-lived alpha emitters that spread throughout the tumor volume primarily by diffusion. Alpha dose calculations in DaRT are based on describing the transport of alpha emitting atoms, requiring new modeling techniques. Purpose: A previous study introduced a simplified framework, the "Diffusion-Leakage (DL) model", for DaRT alpha dose calculations, and employed it to a point source, as a basic building block of arbitrary configurations of line sources. The aim of this work, which is divided into two parts, is to extend the model to realistic seed geometries (in Part I), and to employ single-seed calculations to study the properties of DaRT seed lattices (Part II). Such calculations can serve as a pragmatic guide for treatment planning in future clinical trials. Methods: We derive a closed-form asymptotic solution for an infinitely long cylindrical source, and extend it to an approximate time-dependent expression that assumes a uniform temporal profile at all radial distances from the source. We then develop a finite-element one-dimensional numerical scheme for a complete time-dependent solution of this geometry and validate it against the closed-form expressions. Finally, we discuss a two-dimensional axisymmetric scheme for a complete time-dependent solution for a seed of finite diameter and length. Different solutions are compared over the relevant parameter space, providing guidelines on their usability and limitations. Results: We show that approximating the seed as a finite line source comprised of point-like segments significantly underestimates the correct alpha dose, as predicted by the full two-dimensional calculation. The time-dependent one-dimensional solution is shown to coincide to sub-percent-level with the twodimensional calculation in the seed midplane, and maintains an accuracy of a few percent up to ∼ 2 mm from the seed edge. Conclusions: For actual treatment plans, the full two-dimensional solution should be used to generate dose lookup tables, similarly to the TG-43 format employed in conventional brachytherapy. Given the accuracy of the onedimensional solution up to ∼ 2 mm from the seed edge it can be used for efficient parametric studies of DaRT seed lattices.
Background: Diffusing alpha-emitters radiation therapy ("DaRT") is a new method, presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies on interstitial seeds carrying 𝜇Ci-level 224 Ra activity on their surface, which release a chain of short-lived alpha emitters that spread throughout the tumor volume primarily by diffusion. Alpha dose calculations in DaRT are based on describing the transport of alpha emitting atoms, requiring new modeling techniques. Purpose: A previous study introduced a simplified framework, the "diffusionleakage (DL) model," for DaRT alpha dose calculations, and employed it to a point source, as a basic building block of arbitrary configurations of line sources. The aim of this work, which is divided into two parts, is to extend the model to realistic seed geometries (in Part I), and to employ single-seed calculations to study the properties of DaRT seed lattices (Part II). Such calculations can serve as a pragmatic guide for treatment planning in future clinical trials. Methods: We employ the superposition of single-seed solutions, developed in Part I, to study the alpha dose in DaRT seed lattices and investigate the sensitivity of the required seed activity and spacing to changes in the DL model parameters and to seed placement errors. Results: We show that the rapid fall-off of the dose, which guarantees sparing healthy tissue already 2-3 mm away from the tumor, strongly favors a hexagonal, rather than square, seed placement pattern. Realistic variations in the seed manufacturing parameters ( 224 Ra activity and emission rate of its daughters) are shown to have a negligible effect on the required lattice spacing.On the other hand, tumor parameters (i.e., diffusion lengths and 212 Pb leakage probability), as well as seed placement errors, have a significant effect. Conclusions:In most cases, hexagonal lattice spacing on the scale of ∼3.5-4.5 mm using seeds carrying a few 𝜇Ci/cm 224 Ra will enable overcoming realistic uncertainties in measured tumor environment parameters, as well as seed placement errors, and result in therapeutically relevant alpha dose levels.
The phenomenon of avalanche-gain variations over time, particularly in Micro Pattern Gaseous Detectors (MPGD) incorporating insulator materials, have been generally attributed to electric-field modifications resulting from "charging-up" effects of the insulator. A robust methodology for characterization of gain-transients in such detectors is presented. It comprises three guidelines: detector initialization, long-gain stabilization monitoring and imposing transients by applying abrupt changes in operation conditions. Using THWELL and RPWELL detectors, we validated the proposed methodology by assessing a charging-up/charging-down model describing the governing processes of gain stabilization. The results provide a deeper insight into these processes, reflected by different transients upon abrupt variations of detector gain or the irradiation rate. This methodology provides a handle for future investigations of the involved physics phenomena in MPGD detectors comprising insulating components.
Concomitant with this increase will be an increase in the number of interactions in each bunch crossing and a significant increase in the total ionising dose and fluence. One part of this upgrade is the replacement of the current endcap calorimeters with a high granularity sampling calorimeter equipped with silicon sensors, designed to manage the high collision rates [2]. As part of the development of this calorimeter, a series of beam tests have been conducted with different sampling configurations using prototype segmented silicon detectors. In the most recent of these tests, conducted in late 2018 at the CERN SPS, the performance of a prototype calorimeter equipped with ≈12, 000 channels of silicon sensors was studied with beams of high-energy electrons, pions and muons. This paper describes the custom-built scalable data acquisition system that was built with readily available FPGA mezzanines and low-cost Raspberry PI computers.
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