Dental pulp tissue from three elephants was examined histologically with hematoxylin and eosin and s-100 protein stains. In all specimens, normal pulp was found with the exception that no nerve fibers (myelinated or non-myelinated) were demonstrable in any of the numerous sections prepared.
Estradiol-17P metabolism was studied in two female Asian elephants (Elephas maximus). In an initial study, 500 pCi of tritiated estradiol-17P was injected iv into a single animal, and 0, 30 and 60 min serum samples were collected as well as all excreted urine and feces for 24 hr. In a second study, 1.5 mg unlabeled estradiol-17P was injected iv into a second animal and 0, 5 , 15, 30, and 60 min serum samples and a 30 min urine sample were collected postinjection. Analyses of samples from both studies demonstrated a rapid conversion of free estradiol to conjugated forms in the serum. The first (5 min) serum sample following the injection of unlabelled estradiol contained unconjugated estradio1:conjugated estradio1:conjugated estrone at a ratio of 60:29:10, respectively, and at 30 min a ratio of 33:43:24. The urinary estrogen metabolites were in the conjugated form with an estradio1:estrone ratio of 60:40. No radiolabeled estrogen was found in the fecal samples during the 24 hr following administration of the radiolabeled estradiol. These data indicate a rapid clearance of circulating free estradiol in the elephant, with a major metabolite in the serum and urine being estradiol Conjugate. 0 1992 Wiley-Liss, Inc.
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