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Bacillus pasteurii concrete durability calcite precipitation As like humans having the ability to precipitate minerals in the form of bones and teeth continuously, even some bacteria like Bacillus pasteurii and Bacillus sphaericus can continuously precipitate calcite, called as microbiological induced calcite precipitation. The present investigation discusses on the effects of B. pasteurii and B. sphaericus on durability of concrete beams. The efficacy of the bio deposition treatment on concrete beams with bacteria, alkali, sulfate and freeze-thaw environments along with water absorption was studied. The presence of a layer of calcium carbonate and microbial biomass resulted in a decrease of permeation properties of cementation materials. This technique not only improved the concrete strength but also enhanced water impermeability through calcite precipitation, quantified by X-ray diffraction analysis. Hence this biological treatment is highly desirable and eco-friendly. The present work guarantees a biological metabolic outcome with improvement in concrete and building material technology.

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Dendritic nanostructure with the catalytic moiety covalently attached within the core domain and protected from the environment by a polymeric shell was synthesized successfully. This prospective will focus on the exclusive features observed for such a catalytic system with reactive sites present both at the core and the periphery and highlight its potential as enzyme mimics, by synthesizing different bisimidazoles following the MCR method, at room temperature. An unprecedented reaction rate and high yield of products were obtained within a short time, which is supposed to be its ability to form reverse micelle in the core, where the substrates are adequately concentrated. This is the first reported synthesis of bisimidazoles, using the homogeneous PAMAM dendrimer as a basic organocatalyst. The newly synthesized bisimidazoles obtained from bis(3‐aminopropyl)amine were subjected to molecular docking studies against anticancer protein receptor using AutoDock Vina software, to evaluate their activity against breast cancer cell line (3HB5).

Background:Plumbago rosea is used in traditional systems of medicine for the preparation of formulations used for treating inflammations, cough, bronchitis, and gastrointestinal disorders, and also in conjunction with cancer chemotherapy. In the present study, the cytotoxic and anti-proliferative effects of plumbagin, and the ethanolic root extract of P. rosea (ETPR) was evaluated on SK-MEL 28 melanoma cell lines and human lymphocytes.Materials and Methods:MTT and apoptotic assays were used for the evaluation of cytotoxic and anti-proliferative effects, respectively. In addition, the effect of Plumbagin and ETPR in down regulation of BCL-2 expression is investigated using RT-PCR analysis.Results:Both plumbagin and ETPR dose-dependently decreased the cell viability more potently in melanoma cell lines. P. rosea extract demonstrated significant synergy in inhibiting BCL-2 expression than plumbagin. Moreover plumbagin showed more toxicity in human lymphocytes.Conclusion:Plumbagin has anti-cancer potential, but the side effects limits its use; yet plumbagin, in combination with other ingredients in Plumbago rosea extract, displays significant synergy leading to a stronger anticancer effect with significantly less toxicity.

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