Study Objectives: Sarcopenia, or loss of muscle mass, occurs with aging and results in frailty, disability, cardiovascular disease, and insulin resistance. Recently, researchers have asserted that sarcopenia is not an inevitable process, but is a modifiable condition. Adequate sleep duration is also important to maintain good physical and mental health. Therefore, the aim of our study was to examine the association between sleep duration and sarcopenia in Korean adults. Methods: Data from 16,148 participants (7,158 men and 8,990 women) were analyzed from the 2008-2011 Korean National Health and Nutrition Examination Survey (KNHANES). We defined sarcopenia as one standard deviation below the sex-specific means of the appendicular skeletal muscle/height-squared values of a young reference group. Participants were categorized into 5 groups according to sleep duration. The odds ratios (OR) and 95% confidence intervals (95% CI) for sarcopenia according to sleep duration were calculated using multiple logistic regression analysis. Results: The prevalence of sarcopenia was 14.3% in the total population (males 18.7%, females 9.7%). Compared to the 7 hours of sleep group, the OR (95% CI) for sarcopenia of the long sleep duration group (9 hours or more) was 1.589 (1.100-2.295) after controlling for confounding factors. I NTRO DUCTI O NSarcopenia is a condition characterized by the loss of skeletal muscle mass, strength, and function.1 During normal aging in humans, muscle mass decreases by approximately 3% to 5% every 10 years after the age of 30 years.2 Especially in older people, sarcopenia is closely related to frailty, disability, and falls. Furthermore, emerging evidence suggests that sarcopenia is associated with many cardiometabolic diseases such as insulin resistance, diabetes mellitus, and cardiovascular disease.3-6 Although decline in muscle mass is an inevitable process with aging, recent studies suggest that sarcopenia is a modifiable condition, and the rate of decline of muscle mass can be slowed by adopting a healthy lifestyle. The pathophysiology of sarcopenia is multifactorial. Physical inactivity, low body weight, malnutrition, and a reduction in endocrine function have been identified as risk factors in several studies. 7,8An adequate amount of sleep plays an important role in physical health and quality of life. Therefore, researchers have tried to suggest an appropriate sleep duration. Although sleep duration varies across life span, the National Sleep Foundation has recommended that sleep duration be 7 to 8 hours. Considering the aforementioned findings, sarcopenia may be a detrimental preclinical condition that affects the relationship between sleep duration and adverse health outcomes. The association between sleep duration and sarcopenia has not been fully examined. Thus, in this study, we aimed to investigate the association between sleep duration and sarcopenia in Korea using a nationally representative dataset. M ETHO DS Study PopulationThe Korea National Health and Nutrition Examination Survey...
A higher OBS that indicates a predominance of antioxidant over pro-oxidant exposure was strongly inversely associated with GGT level among Korean adults.
ObjectivesThe visceral adiposity index (VAI), an indirect marker of visceral adipose tissue, serves as a model associated with cardiometabolic risk, but has limitations regarding the Asian population. We sought to develop a new VAI (NVAI) for the Korean population and compare it to VAI for prediction of atherosclerotic cardiovascular disease (ASCVD) risk and development of major cardiovascular diseases (CVD) and stroke.MethodsPatients (969) who underwent visceral fat area measurement were analyzed. After exclusion, 539 patients (142 men, 397 women) were randomly divided into internal (n = 374) and external validation (n = 165) data set. The NVAI was developed using univariate and multivariate logistic regression with backward selection of predictors. Receiver operating characteristic (ROC) curve analysis and comparison of the area under the curve (AUC) verified the better predictor of ASCVD risk score. Additionally, nationwide population-based cross-sectional survey data (Korean National Health and Nutrition Examination Survey [KNHANES] 2008–2010, n = 29,235) was used to validate the NVAI’s ability to predict ASCVD risk and major CVD and stroke.ResultsThe NVAI better reflected visceral fat area in internal and external data sets, with AUCs of 0.911 (95% confidence interval [CI]: 0.882–0.940) and 0.879 (95% CI: 0.828–0.931), respectively. NVAI better discriminated for ASCVD risk (AUC = 0.892, 95% CI: 0.846–0.938) compared to VAI (0.559, 95% CI: 0.439–0.679). The NVAI also better predicted MI or angina, and stroke with AUCs of 0.771 (95% CI: 0.752–0.789), and 0.812 (95% CI: 0.794–0.830), respectively, compared with waist circumference (WC), body mass index (BMI), TG to HDL ratio, and VAI via KNHANES, in a statistically significant manner.ConclusionsThe NVAI has advantages as a predictor of visceral obesity and is significantly associated with ASCVD risks and development of major CVD and stroke in the Korean population. The NVAI could be a screening tool for improved risk estimation related to visceral obesity.
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