Various studies have suggested that an increase in circulating corticosteroids may be associated with an increased level of gonadotrophic activity. A series of patients was therefore studied during the administration of corticotrophin (ACTH) to see if this caused an increase in their urinary gonadotrophin. The patients were post-menopausal women selected because ACTH was to be given to them to test the responsiveness of their adrenal glands or, in one case, as a form of treatment. They had all been in hospital for several days before the test. Corticotrophin gelatin injection (BP) was given intramuscularly in doses of 40 i.u. 8-hourly for six doses. In all cases a vigorous response was shown by measurements of urinary or plasma corticosteroids. This response was examined in relation to the changes in urinary gonadotrophin but no obvious relationship was observed. The values for the corticoid estimations are therefore not shown in Table 1.
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