Measuring testosterone was not helpful in assessing potency or libido and low serum levels were not related to age. Correcting low testosterone did not improve either impotence or libido.

Background and Objective Recent COVID‐19 pandemic guidelines recommend genomic assessment of core biopsies to help guide treatment decisions in estrogen receptor (ER)‐positive early‐stage breast cancer. Herein we characterize biopsy and excisional breast cancer specimens submitted for 21‐gene testing. Methods US samples submitted to Genomic Health for 21‐gene testing (01/2004‐04/2020) were assessed by pathologists and analyzed by a standardized quantitative reverse transcription‐polymerase chain reaction. Predefined cutoffs were: ESR1 (positive ≥6.5), PGR (positive ≥5.5), and ERBB2 (negative <10.7). ER status by immunohistochemistry (IHC) and lymph node status were determined locally. Median and interquartile range were reported for continuous variables, and total and percent for categorical variables. Distributions were assessed overall, by age, and by nodal involvement. Results Of 919 701 samples analyzed, 13% were biopsies and 87% were excisions. Initial assay success rates were 94.5% (biopsies) and 97.3% (excisions). ER IHC concordance with central ESR1 was 96.8% (biopsies) and 97.6% (excisions). Biopsy and excisional medians were: Recurrence Score results 16 (each); ESR1 10.2 (each); PGR 7.7 and 7.6; ERBB2 9.4 and 9.2, respectively. Conclusions Biopsy submissions for 21‐gene testing are common and consistently generate results that are very similar to the experience with excisions. The 21‐gene test can be performed reliably on core biopsies.

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Secondary testicular tumours are rare. A case is described of testicular tumour, the only apparent metastasis of long-standing carcinoma of the prostate gland. Case ReportC.G. presented at the age of 64 with urinary difficulty and haematuria. IVU and serum acid phosphatase estimation were normal. At rectal examination it was considered that the patient had Stage I1 carcinoma of the prostate and moderately differentiated carcinoma was Cobb, 0. E., Lane, F. C. and Anderson, E. E. (1966). Vasocutaneous fistula. ~ournal of Urology, 95, 788-790. Hanley, H. G. (1945). Urinary fistula following scrotal vasectomy. British Journal of Urology. 17, 54-55. Henriet, R. (1976). Fistule urinaire scrotale par reflux urtthrcdeferentiel. Journal durologie et de Nephrologie, 82, 523-524.