The metabolic transformations of the psychotropic cannabinoid (3R, 4R)-A1tetrahydrocannabinol (5) (= A'-THC) by cultures of Fusarium nivale, Gibberella fujikuroi (both Ascomycetes) and Thamnidium elegans (Phycomycetes) were investigated. A number of metabolites, 1-4 and 6-9 were isolated from the incubations, partly purified and their structures elucidated by combined gas chromatography/mass spectrometry. Four of these metabolites, 1"-hydroxy-A'-THC (4), 2"-hydroxy-A1-THC (l), 6B-hydroxy-A'-THC (8) and 2", 6 (-dihydroxy-A'-THC (9) so far have not been reported as microbial transformation products of 5 .
Das psychotrope Cannabinoid (Ia) wird durch Inkubation mit Thamnidium elegans zu den Metaboliten (Ib)‐(Ii) hydroxyliert " ;(Ib)‐(Id) entstehen auch bei der enzymatischen Hydroxylierung von (Ia) mit Fusarium nivale oder mit Gibberella fujikuroi.
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