SYNOPSIS IN INTERLINGUA ALTERATIONES PATHOLOGIC IN LE INNERVATION DEL PULPA DENTAL IN LE PROCESSO CAMOSE.—In dentes in le quales le structura del pulpa esseva love-, o fortemente alterate, typic alterationes in le plexo neural del pulpa esseva observate. Minor alterations pathologic del pulpal rete neural appareva in le forma de un pronunciate argyrophilia e de un augmentate brancage in le rete preterminal e terminal. In casos de inflammation del pulpa o del formation de abscessos, esseva notate un relaxation del fasces neural, a vices un abundante brancage irregular de nervos, irregular spissification o intense crudification del fibras neural, e decomposition del fasces ad in plus micre unitates, e fragmentation del fibras neural.
Mineralized plaques, which develop at the site of repeated subcutaneous injections of 100 mug KMnO4/0.2 H2O in rats, were investigated by electron microscopy. The newly formed, delineated, white plaque tissue at the injection site consisted of numerous, mostly unaltered fibroblasts and collagen fibers, without participation of inflammatory cells. Some signs of cell injury were found in the center of the lesions. Numerous, irregularly distributed, small, mineralized foci were seen near the fibroblasts. These were formed by aggregation of small needle-like units (50 A in diameter and 0.05-2.0 mum long). These needle-shaped units were found either in vesicular, cell derived structures, considered to be shed cell fragments, or on collagen fibers. Intramitochondrial deposits of such needle like units were seen frequently. Fusion of smaller mineralized foci to larger plaques occured and then needle-shaped units were seen at the periphery of the electron-dense lesions. Hypotheses concerning the mechanism of experimental cutaneous calcinosis (soft tissue mineralization) are discussed and related to the findings of this study. Probable intracellular crystal deposition and mineralization in cell-derived structures were shown for the first time in topical cutaneous calcinosis.
The difficulties in impregnating bony tissues, which occur after decalcification with acids or electrolysis are avoided by decalcification with ethylenediaminetetraacetic acid at pH 8.2-8.5. The decalcification of adult human teeth which have been Cut to a thickness of 2-5 mm takes 1-2 mo. I f frozen sections of the decalcified teeth are impregnated 24 hr in 20%AgNo, , rinsed through 6 changes of 20% neutralized (CaCO,) formalin, blotted thoroughly
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