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After the adoption of green revolution, India has combined action of cypermethrin and methanolic extracts of Coriandrum sativum, Piper nigrum observed for their larvicidal and pupicidal activites against Aedes aegypti. When analyzed individually, Cypermethrin were found to be most effectual against the first instar larvae of Aedes aegypti, methanolic extracts of Piper nigrum, sativum being least effective. The LC obtained with Cypermethrin and methanolic extracts of Piper nigrum, Coriandrum sativum against the first instar larvae were 0.61, 0.71 and 0.86%, respectively and the LC 90 values were 1.32, 2.73 and 3.71% respectively. The combination of Cypermethrin and Coriandrum sativum was studied at mixed with Cypermethrin 0.5% and Coriandrum sativum 1.5, 2.0 and 2.5. Similar mixtures were also used for the combination of Cypermethrin and The Cypermethrin and Coriandrum sativum extract combination acted antagonistically. The combination of Cypermethrin and Piper nigrum extract acted synergistically against the target organisms at a first instar larvae, which showed the best results of: LC 50 0.58 and LC 90 2.40% at 24 hours, respectively. The present study will be helpful in developing in a commercial formulation for effe vector management.

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