Objective To eva luate the therapeutic efficacy of intravesica l pentosanpolysu lph ate (PPS) compared with placebo in patients with interstitial cystitis (rC). Patients and methods Twenty patients who fullfilled the diagnostic criteria for IC participated in a double-blind placebo-controlled study: 10 received intravesical PPS (300 mg in SO mL of 0.9% sodium chloride) applied twice a week for 3 months and the other 10 received a placebo. Symptomatic relief and objective variables (bladder capacity voiding volumes and urinary frequency) were assessed after 3 months and the long-term outcome of those continuin g treatment was determined. Results Of the patients treated with PPS, four gained
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