The metabolic activity of the red cell glycolytic
pathway hexose monophosphate shunt (HMP) with dependent
glutathione system was studied in patients with hyperthyroidism
(n = 10), hyperlipoproteinemia (n = 16), hypoglycemia (n = 25)
and hyperglycemia (n = 23). In uncontrolled diabetics and patients
with hyperthyroidism the mean value of glucose phosphate
isomerase (GPI), glucose-6-phosphate dehydrogenase (G-6-PD),
glutathione reductase (GR) was increased, whereas these enzyme activities were reduced
in patients with hypoglycemia. Apart from a few values of hexokinase (HK) which were
lower than normal the results in hyperlipoproteinemia patients remained essentially
unchanged, including the intermediates such as 2,3-diphosphoglycerate (2,3-DPG),
adenosine triphosphate (ATP) and reduced glutathione (GSH). While increased rates of
2,3-DPG and ATP in hypoglycemia patients were obtained, these substrates were markedly
reduced in diabetics.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.