Background Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes. Methods Three hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011. Based on the year of their transplantation, the patients were divided into 3 eras: (1983-1992 [era 1], 1993-2002 [era 2], and 2003-2011 [era 3]). Results In eras 1, 2, and 3, the proportions of patients with PTDM at 1 versus 3 years were 23% versus 39%, 21% versus 26%, and 33% versus 38%, respectively. Independent risk factors predicting PTDM at one year were recipient's age, duration of cold ischemic time, treatment with furosemide, and tacrolimus. There was a trend for overall survival being worse for patients with PTDM in comparison to patients without PTDM (p = 0.08). Patients with PTDM exhibited a significantly higher rate of renal failure over a median follow-up of 10 years (p = 0.03). Conclusion The development of PTDM following cardiac transplantation approaches 40% at 3 years and has not significantly changed over thirty years. The presence of PTDM is weakly associated with an increased mortality and is significantly associated with a worsening in renal function long-term following cardiac transplantation.

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U tests were used to calculate significance for continuous variables. The significance level was set at 0.05. Results: We reviewed 124 consecutive OHTs performed at our hospital from 2004-2014. Of these, 50 cases (40.3%) experienced UEDVT. PE occurred in one patient (2%) and UEDVT recurred in 11 (22%). 20 patients were anticoagulated (40%) and 19 (38%) suffered bleeding complications. There was no significant difference in survival, UEDVT recurrence, PE, or number of bleeding complications at one year between those on anticoagulation versus those who were not. In those with UEDVT, there were 1,357 total days spent on anticoagulation and 9 bleeding events for an average of one bleeding event per 150.7 days. In comparison, there were 16,893 total days without anticoagulation, and 16 bleeding events during this time, yielding an average of one bleed every 1,055.8 days. Additionally, patients who suffered bleeding complications had a 15.8% lower one year survival rate (p = 0.049). Conclusion: UEDVT was common in our post-OHT population. We found no significant difference in recurrent UEDVT or PE between those who were anticoagulated and those who were not. However, we discovered an increased daily bleeding risk of approximately seven-fold while on anticoagulation. Also, survival one year from OHT was significantly lower in those who experienced a bleed. The decision of whether to anticoagulate OHT patients with UEDVT should be made with careful attention to bleeding risk.

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AimTo investigate the effect of the new definition of pulmonary hypertension (PH) and new pulmonary vascular resistance (PVR) thresholds on the prevalence, clinical characteristics, and events following cardiac transplantation (CTx) over 30 years.MethodsPatients who underwent CTx between 1983 and 2014 for whom invasive hemodynamic data was available were analyzed (n = 342). Patients transplanted between 1983 and 1998 were classified as early era and those transplanted between 1999 and 2014 were classified as recent era. Group 2 PH was diagnosed in the presence of a mean pulmonary artery pressure (mPAP) > 20 mmHg and pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Isolated post capillary PH (Ipc-PH) was defined as PVR ≤ 2 wood units and combined pre and post capillary PH (Cpc-PH) was defined PVR > 2 wood units. Moderate to severe PH was defined as mPAP ≥ 35 mmHg. The primary outcome was 30-day mortality and long-term mortality according to type and severity of PH. Proportions were analyzed using the chi-square test, and survival analyses were performed using Kaplan-Meier curves and compared using the logrank test.ResultsThe prevalence of PH in patients transplanted in the early era was 89.1%, whilst 84.2% of patients transplanted in the recent era had PH (p = 0.3914). There was no difference in the prevalence of a pre-capillary component according to era (p = 0.4001), but severe PH was more common in the early era (51.1% [early] vs 38.0% [recent] p = 0.0151). Thirty-day and long-term  mortality  were  not  significantly  associated  with severity or type of PH. There was a trend toward increased 30-day mortality in mild PH (10.1%), compared to no PH (4.4%) and moderate to severe PH (6.6%; p = 0.0653). Long-term mortality did not differ according to the severity of PH (p = 0.1480). There were no significant differences in 30-day or long-term mortality in IpcPH compared to CpcPH (p = 0.3974 vs p = 0.5767, respectively).ConclusionOver 30 years, PH has remained very prevalent before CTx. The presence, severity, and type (pre- vs post-capillary) of PH is not significantly associated with short- or long-term mortality.

Fish bone is the commonest pharyngeal foreign body, however migrating fish bone is a rare occurrence. We report a case of a 54-year-old male who had history of fish bone ingestion over a week and presented with odynophagia and worsening neck pain. Rigid esophagoscopy revealed tip of a fish bone which was embedded in granulation tissue. The fish bone migrated further with manipulation. Aided with computed tomography scan findings, the serrated fish bone was finally removed via transcervical approach without any complication. In conclusion, high index of suspicion and prompt removal of migrating fish bone with the aid of computed tomography imaging is necessary to avoid fatal complications.

Introduction: Surgery is indicated for acute appendicitis but there is controversy regarding precise timing for appendectomy.Objective: Our aim was to evaluate the impact of time delay from emergency department presentation to surgery in developing complicated appendicitis in children and associated morbidity.Methods: 540 charts of children, who underwent appendectomy, between January 2013 and December 2016 were retrospectively reviewed. Groups were divided by time of intervention. Group 1: less than 24h (n=209, 38.7%), group 2: 24h to 48h (n=293, 54.5%), and group 3: greater than 48h (n=38, 6.8%). We considered complicated appendicitis gangrenous, abscess or perforated appendix per operatively and on histopathologic examination. Statically analysis and was performed to search the predictors of complicated appendicitis and evaluate postoperative complications.Results: Among 540 children included in the study, 164 (30.4%) had complicated acute appendicitis. There was no correlation between delay to surgery and the risk of developing a complicated form of the disease for group 1 and Group 2. Beyond the 48 th h (group 3), the rate of developing complicated appendicitis and post-operative complications increased significantly. Hospital stay was not affected by delayed surgery. Conclusion:A short in-hospital delay before surgery less than 48 h, for acute appendicitis in child, is not associated with an increased rate of complex appendicitis neither associated morbidity.

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