We describe a crystal structure, at atomic resolution (1.1 Å, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51°kinking of the double helix. The complex cation Λ-½Ruð1,4,5,8-tetraazaphenanthreneÞ 2 ðdipyridophenazineÞ 2þ crystallizes in a 1∶1 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.DNA oligonucleotide | ruthenium complex | X-ray crystal structure

No abstract

No abstract

No abstract

No abstract