The review is focused on the role of matrix metalloproteinases and their inhibitors in the development of myocardial remodeling after infarction of the heart muscle. the article describes the structural features of proteases and their function in the body, levels of control of their synthesis and their action function together with the natural inhibitors. The paper shows data of numerous authors, which reflect information regarding the activity of metalloproteinases and their inhibitors at different times after the development of myocardial necrosis in humans and simulated heart attack in different animals.
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