Резюме. Вторая часть обзора посвящена вариантам модификации металлических стентов для ускоре-ния эндотелизации in situ. Представлены разработки. направленные на захват эндотелиальных прогени-торных клеток из кровотока с помощью специфических антител. Описаны возможности улучшения адгезии и интеграции эндотелиальных клеток на поверхности за счет формирования сайтов клеточного распозна-вания и имитация структур внеклеточного матрикса. Проанализированы различные способы физической и химической модификации, способствующие созданию условий для скорейшего формирования функцио-нально состоятельного эндотелиального слоя на искусственных поверхностях. Определен круг проблем и ограничений в использовании каждого из методов.Ключевые слова: металлические стенты, рестеноз, модификация поверхности, эндотелизация. Here we review the modifications of the metal stents to enhance in situ endothelialization, particularly antibody-mediated adhesion of endothelial progenitor cells. We focus on the strategies employing cell adhesion molecules and extracellular matrix proteins. We also encompass other physical and chemical approaches for surface biofunctionalization with their advantages and shortcomings. SURFACE MODIFICATION OF BARE-METAL STENTS FOR PREVENTING RESTENOSISKeywords: bare-metal stents, restenosis, surface modification, endothelialization НИИ КПССЗ имеет большой опыт в разработке изделий для сердечно-сосудистой хирургии, в частности биопротезов кла-панов сердца и сосудов. С 2010 года под руководством академика РАН л. С. Барбараша начаты исследования по созданию био-резорбируемых сосудистых протезов малого диаметра. Основная цель -создание полимерных конструкций с бионаправленным действием, способных заменить отдельные структуры живого организма, в частности сердечно-сосудистой системы. Научная но-визна поставленной задачи заключается в использовании нового подхода создания органа непосредственно в организме пациента за счет биофункциональности и биорезорбируемости полимерных конструкций. доказана долгосрочная проходимость полимерных сосудистых графтов на основе поликапролактона и композиции полигидроксибутирата/валерата и поликапролактона. В экспери-ментах in vitro доказано, что ростовые факторы, инкорпорируемые в состав биодеградируемых графтов, сохраняют свою био-логическую активность. В долгосрочных экспериментах in vivo доказано, что сосудистый эндотелиальный фактор роста ускоряет эндотелизацию и улучшает проходимость биодеградируемых полимерных сосудистых графтов.Ключевые слова: биодеградируемые полимеры, сосудистый графт, ростовые факторы. DEVELOPMENT OF TISSUE ENGINEERED SMALL DIAMETER VASCULAR GRAFT FOR THE CARDIOVASCULAR SURGERY NEEDS L. V. ANTONOVA, YU. A. KUDRYAVTSEVA Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, RussiaRICICd has large experience in the development of products for cardiovascular surgery, in particular, the bioprosthesis heart valves and blood vessels. Since 2010, under the leadership of the academician of RAS L. S. Bar...
Recently, the share of non-design fuel use of coal at thermal power plants has increased, which negatively affects the operation of existing equipment. On the territory of the Irkutsk Region, there are 9 combined heat and power plants operating mainly on brown coals of the Irkutsk and Kansk-Achinsk basins. The main fuel at many CHPs is brown coal from the Mugunskoye deposit, the quality of which is deteriorating year by year. At the Novo-Irkutsk CHP, there is a prospect of continuing the supply of the Mugunsky coal with a sulfur content of up to 2.5%, which significantly exceeds the sulfur content of the design coals, which is 0.5%. This leads to the condensation of sulfuric acid vapors in the flue gases and, as a result, the heating surfaces are subject to sulfuric acid corrosion. In addition, there is a problem of erosive wear of air heaters at CHPs, caused by high flow rates and ash concentrations, which is also caused by a deterioration in the composition of the burnt coal. To solve the problem associated with low-temperature sulfuric acid corrosion of the boiler air heater tanks, it is proposed to place additional heating surfaces in the bypass gas ducts, which will reduce the temperature of the gases by cooling the flue gases with network water, and allow the obtained heat to be used in the added sections of the calorifier for heating the inlet (cold) air. While bypassing 25% of gases using the heat of gases in the calorifiers, erosion wear is reduced due to a decrease in the gas velocity in the air heater from 13 m/s to 9 m/s. The proposed technical measures will make it possible not only to increase the efficiency of the boiler and the plant as a whole, but also to increase the degree of fuel heat use.
Proposed is a method of processing and recycling solid household wastes (SHW) by combustion in boiler furnaces together with irring - Borodin coal. The technology of preliminary sorting with the list of necessary equipment and works is presented. Thermal calculations of the boiler were performed BBP-420-140-6 on combined combustion of SHW and coal in different ratios. Technological solution is proposed, which allows to dispose of sorted solid household wastes during combustion in furnaces together with coal in different ratios.
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