The 2-cyano-2-isonitrosoacetamide, NC-C(N=OH)-C(O)NH(2) (1), its Na(+), Cs(+) salts and four silver(I) complexes with N-donor ligands were synthesized and characterized using a variety of techniques including IR, UV-vis spectroscopy, solid state photoluminescence, X-ray analysis, and solution electrical conductivity. All four reported here Ag(I) complexes were crystallographically characterized and revealed completely different structures. Thus, the combination of chelate and bridging function of the cyanoxime anion in Ag{NC-C(N=O)-C(O)NH(2)} (complex 6) leads to a unique layered 2D coordination polymer of silver(i) with pronounced argentophilic interactions at 3.194 A. The structure of Ag{NC-C(N=O)-C(O)NH(2)} x 2Pic (Pic = 2-methylpyridine; complex 7) represents the monomeric complex containing bidentate chelate anion 1(-). The crystal structure of monomeric Ag{NC-C(N=O)-C(O)NH(2)} x 2NH(3) (complex 8) reveals the formation of a linear Ag(NH(3))(2)(+) cation non bonded to the metal cyanoxime anion 1(-). This is the first structure of a silver(i) diammine cation with an oxime-based anion. Similarly to 8, the crystal structure of Ag(14ane[N(4)]){NC-C(N=O)-C(O)NH(2)} x CH(3)CN with tetraaza-meso(macrocyclic) ligand (complex 9) contains a metal center not bound to the cyanoxime ligand as well. Instead, the agostic interaction at 2.591 A between the methylene group of the macrocyclic ligand and silver(I) center was found in 9. This is the shortest CH(2)-Ag distance between an aliphatic group and metal observed so far in non-organometallic silver complexes with neutral ligands. We also documented a remarkable visible-light insensitivity of complex 6. Room temperature solid state photoluminescence of this compound was examined in details, including studies of its emission in the presence of several gases of industrial importance: H(2), CO, NO, NH(3), SO(2), acetylene C(2)H(2) and ethylene C(2)H(4). A significant sensitization of to visible light after the exposure was observed, which is a useful property that may be utilized in development of battery-less colorimetric sensors for these gases.
ЦельCOVID-19, как и другие респираторные вирусы, имеет внелегочные проявления. В частности, воздействие вируса приводит к поражению сердечно-сосудистой системы (ССС), патофизиологические механизмы которого до конца не ясны; не сформировано полноценное понимание механизмов взаимодействия COVID-19 и ССС. В статье проанализированы современные представления о COVID-19, рассмотрены возможные звенья патогенеза, предпринята попытка систематизации патофизиологических механизмов поражения ССС и их осложнений, проанализирована связь с сердечно-сосудистой коморбидностью, описаны особенности патоморфологии и предположительный долгосрочный прогноз. Представленные сведения могут способствовать пониманию двустороннего взаимодействия кардиоваскулярных заболеваний и эффектов COVID-19 для разработки эффективных профилактических мер и принятия верного решения в выборе терапевтической тактики для пациента в рамках системного подхода.
ong-term consequences of COVID-19 remain the subject of active research interest. In this article the Post-COVID-19 syndrome (PCS) main features and symptoms are considered, its incidence and link with comorbidity is presented and the possible mechanisms are discussed. Due to the damage COVID-19 has on lungs, heart, brain and other systems, patients with PCS require multidisciplinary management.
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