Resumo Visando avaliar a resposta imunológica produzida por vacinas anti-rábicas em primatas não humanos neotropicais, trinta sagüis (Callithrix sp) foram divididos em cinco grupos de seis indivíduos e submetidos a cinco diferentes esquemas de vacinação anti-rábica, utilizando-se duas vacinas animais distintas existentes no mercado. A primeira produzida em cérebro de camundongos lactentes (Fuenzalida e Palacios), e a segunda, em cultura de células NIL-2. Acompanhamento sorológico pós-vacinal foi realizado periodicamente. Os resultados mostraram que a vacina Fuenzalida e Palacios não foi eficaz para a proteção dos animais, utilizando-se uma única dose ou mesmo com o reforço. Porém, os sagüis apresentaram anticorpos detectáveis, ao adotar-se o esquema semelhante ao de pré-exposição indicado para os seres humanos, e apenas um animal contraiu raiva após o desafio viral. Por outro lado, a vacina produzida em cultura de células NIL-2 produziu elevados títulos de anticorpos em todos os animais imunizados e todos os animais resistiram ao desafio viral. Palavras-chaves: Raiva. Vacina. Imunização. Sagüi. Callithrix sp.Abstract In order to evaluate the immune response produced by rabies vaccines in new world nonhuman primates, thirty marmosets (Callithrix sp) were divided into five groups of six individuals and submitted to five different antirabies vaccination schemes using two distinct commercially available animal vaccines. The first was produced in suckling mouse brain (Fuenzalida and Palacios), and the second in NIL-2 cell culture. Post-vaccine serological monitoring was carried out periodically. The results showed that the Fuenzalida and Palacios vaccine was not able to protect the animals when using a single dose or even with a booster. But when submitted to a vaccination routine similar to that used for humans, the marmosets showed detectable antibodies, and only one succumbed to rabies after being challenged. In addition, the vaccine produced in NIL-2 cell culture induced high antibody levels in all vaccinated animals and all animals survived the viral challenge. Key-words: Rabies. Vaccine. Immunization. Marmoset. Callithrix sp. Dentre as numerosas zoonoses conhecidas, a raiva é considerada uma das mais importantes, devido ao seu desenlace invariavelmente fatal 24 . Assim, todos os cuidados devem ser tomados a fim de que se possa preservar as espécies suscetíveis e a sua profilaxia é a adoção mais importante, seja pelos aspectos de saúde pública, seja pelos aspectos econômicos. Atualmente, são adotados programas de controle da raiva através de rotinas de vacinação anual dos animais domésticos. Os animais silvestres, no entanto, se encontram permanentemente
Forty-five patients with systemic lupus erythematosus (SLE) underwent a cross-sectional study to evaluate intestinal secretory immunity. Peroral jejunal biopsy with histologic and immunohistochemical assessment of the mucosa were carried out in the patients and in 12 healthy volunteers. It was observed that an altered pattern of immunoglobulin-bearing plasma cells distributed in the lamina propria and complementary components were invariably present, mainly in the patients with active disease. The basement membrane of the intestinal crypt epithelium exhibited immunoglobulin and complementary deposits, similar to the lupus band test. None of the immunologic findings correlated with the medical treatment and with the peripheral blood analysis. The local changes in humoral immunity in patients with SLE did not correlate with gastrointestinal symptoms and may reflect the systemic effects of the disease.
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