The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We reviewed a total of 102 tissue samples from patients in our tumour registry, with either primary or metastatic lung or colorectal adenocarcinoma. Tissue sections were stained for cytokeratin 7 and 20 and read as positive or negative for staining. Clinical and radiologic information was reviewed from computerised charts. The cytokeratin 7+/cytokeratin 207 pattern characterised 96% (29 out of 30) of primary and 95% (21 out of 22) of metastatic lung adenocarcinomas. All the primary (26), and 88% (21 out of 24) of metastatic colorectal adenocarcinomas stained cytokeratin 77/cytokeratin 20+. Samples from a variety of metastatic sites were evaluated for cytokeratin 7 and 20 staining. Out of the 102 samples, in 95% (97 out of 102) of the cases, the cytokeratin 7 and cytokeratin 20 staining pattern characterised and differentiated between lung and colorectal adenocarcinoma. Primary and metastatic lung adenocarcinomas show a cytokeratin 7+/cytokeratin 207 staining pattern, while colorectal adenocarcinomas stain cytokeratin 77/cytokeratin 20+. Cytokeratin staining is helpful in the diagnostic differentiation of metastatic lesions from these two common primaries, and assists in determining the site of origin of metastatic lesions.
Objective: This study aims to assess the prevalence of peripheral neuropathy in patients undergoing potentially neurotoxic chemotherapy for breast cancer. Methodology: This is a longitudinal study to assess the prevalence of peripheral neuropathy in women with breast cancer undergoing chemotherapy at the Hospital das Clínicas, Universidade Federal de Goiás (HC-UFG). The study was approved by the Ethics and Research Committee of HC-UFG, and all participants signed an informed consent form. For the data collection, two instruments were used, namely, Sociodemographic Form and Antineoplastic-Induced Neurotoxicity Questionnaire (AINQ). The Microsoft® Excel 2007 was used to tabulate the data, and the statistical analysis was performed using the SPSS® for Windows® program, version 22.0. Results: A total of 30 patients were included in this study. The average age was 51.2 years, and the sociodemographic evaluation showed that the majority of the participants were married (60%), 46.7% had one or two children, 23.3% were unemployed, and the schooling time was 9.88 years. As for the analysis of the AINQ in the three moments of the study, there was no statistical difference between the use of chemotherapy, body mass index, and age for a higher incidence of symptoms of peripheral neuropathy. The prevalence of symptoms of peripheral neuropathy in the sample was 83.3%, with orofacial symptoms being the most reported (grades 1 and 2). Conclusion: The study confirmed the high prevalence of neurotoxicity symptoms related to chemotherapy, both acute and chronic. The persistence of chronic symptoms suggests that, if chemotherapy-induced peripheral neuropathy (CIPN) is correctly diagnosed, it will be possible to control it early, avoiding further damage to patients.
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