During pregnancy, the thyroid volume (TV) increases by 20% to 35% in areas with iodine deficiency. In iodine-sufficient countries, while some studies showed an increase in TV by 10-15%, others did not observe any change in TV during pregnancy. Thyroid nodules may be present in up to 15-35% of pregnant women in areas with moderate iodine deficiency. However, in areas with iodine-sufficient, thyroid nodules were investigated in a few number of studies-In an iodine-sufficient area as Spain, during pregnancy, the TV increase by 13.63% and is associated with urine iodine concentration. Thyroid nodules were present in 10.73% of pregnant women and did not increased in the 3T.
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