This study confirmed that maternal therapy with intravenous immunoglobulin for fetal alloimmune thrombocytopenia gives satisfactory results. It also showed that a less invasive approach, especially a reduction in the number of fetal blood samples, is possible without deleterious consequences. This observation suggests also to start IVIG early during pregnancy and to continue treatment up to delivery.
Oral poster abstracts for relationships with gestational age (GA), maternal age, race, body mass index (BMI), mean arterial blood pressure (MAP), nicotine/caffeine use, measures of uterine and umbilical artery blood flow resistance. Results: 111 consecutive patients had a complete multi-analyte screen. ANG-2 correlated with PIGF and pp-13 (Pearson 0.484, 0,326). PP-13 correlated with free beta HCG (Pearson 0.386, all p<0.0001). ANG-2 and pp-13 were the only factors related to BMI, while ANG-2 showed the stronger relationships MAP than PIGF. Smoking had a significant impact on pp-13 levels and only PIGF was related to placental Doppler studies ( * =p<0.05, ** =p<0.001, table). PTX-3 had no significant relationships with any study parameter. Conclusion: Of the maternal serum analytes that reflect placental angiogenesis ANG-2 has a closer relationship with maternal vascular risk factors while PIGF relates more strongly to the placental circulation. PP-13 acts as a marker of placental mass illustrating the effects of smoking in the first trimester. These independent relationships support the use of multiple analytes for first trimester screening for placental dysfunction.
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