means differed predictably and significantly across known groups based on the PASI and IGA. Responsiveness effect size estimates were moderate to large (0.6 to 1.4). CDF plots show that the percentage of responders was consistently higher in the treatment arms than placebo across the range of change scores. ConClusions: Results support the reliability, validity, and responsiveness of the PsD and its use as a tool to enhance treatment decisions in patients with moderate-to-severe plaque psoriasis.
A403 sents methods to evaluate working ability and quality of life in natalizumab-treated RRMS patients. Methods: A non-interventional study was performed in Germany. Patients treated with natalizumab for a maximum of three months prior to baseline were eligible for study participation. Demographic and occupational information was collected; DSS and EQ-5D-questionnaires were used. Data were collected at baseline, after 6 months and after 12 months. Main objective was to evaluate productivity per year, by using the formula: (working hours per day*5 days per week*46 working weeks a year) -(days absent from work*working hours per year). To assess health economic cost savings, productivity has been valued monetarily by calculating a daily rate of working costs. Subgroup analysis divides the study population into employed, unemployed, patients with statutory sick pay and students. Analyses of variance and subsequent post hoc tests will be performed to identify subgroup differences. Results: Of 95 patients included by January 2014, 46.3% were employed. Average hours worked/day were 5.3 hours (employed: 6.5 hours); average number of days absent from work during the past half-year was 17.4 days (employed: 16.5 days). Calculated productivity per 6 months results in 569.6 hours (employed: 661.0), meaning 6,5540.40€ (employed: 7,634.55€ ) in monetarily valued productivity. ConClusions: This non-interventional study aimed at providing new insights in the therapy of RRMS patients treated with natalizumab. The study's intention was to show how an increase in working hours in employed patients as well as a decrease in days absent from work can lead to an increase in productivity.objeCtives: Relapsing remitting multiple sclerosis (RRMS) is a chronic inflammatory disease representing the most common chronic neurological disorder in young adults. RRMS usually leads to permanent disability and as a result is a major cause of reduced working capacity due to neurological diseases. This abstract pre-
Ceiling effects for "Administration" "Effects" and "Overall Satisfaction" domains were also > 40%, which implied high levels of satisfaction in these areas. For CSPQ, ceiling effects for "Image Quality" was 33.3%. Internal consistency was strong in most instances [PSPQ: "Preparation" (α = .93), "Reaction to Agent" (α = .40); CSPQ and mCSPQ: "Preparation" (α = .99, .99) and "Administration" (α = .93, .92). Inter-item correlations for PSPQ ranged from -0.01 to 0.96, which are small to strong; CPSQ ranged from 0.15 to 0.96, which are small to strong; mCPSQ ranged from 0.81 to 0.99, which are strong. ConClusions: Results suggest that when administered in real-world clinical settings, the PSPQ, CPSQ, and mCPSQ are capable of generating scores across the distribution of available responses (though clustering at upper and lower bound was observed in some instances), that are sufficiently reliable for most research purposes.
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