A new sterol, 23,24(S)-dimethylcholest-5,22-dien-3beta,7alpha-diol (1), has been isolated from the soft coral Lobophytum crassum and characterized by interpretation of spectral data.
A highly stereoselective approach to the total synthesis of the γ‐lactone derivative botryolide E and tetrahydropyran derivative ophiocerin C via a common polyketide precursor by means of Prins cyclization and MacMillan α‐aminoxylation sequence is described. The method can conveniently be utilized for the preparation of further related γ‐lactone and tetrahydropyran derivatives.
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