Quality Assurance (QA) in hadron therapy is crucial to ensure safe and accurate dose delivery to patients. This can be achieved with fast, reliable and high-resolution detectors. In this paper, we present a novel solution that combines a triple Gas Electron Multiplier (GEM) and a highly pixelated readout based on a matrix of organic photodiodes fabricated on top of an oxide-based thin-film transistor backplane. The first LaGEMPix prototype with an active area of 60 × 80 mm2 was developed and characterized using low energy X-rays. The detector comprises a drift gap of 3.5 mm, a triple-GEM stack for electron amplification, and a readout featuring 480 × 640 pixels at a 126 µm pitch. Here, we describe the measurements and results in terms of spatial resolution for various experimental configurations. A comparison with GAFCHROMIC® films and the GEMPix detector used in the charge readout mode was performed to better understand the contribution to the spatial resolution from both the electron diffusion and the isotropic emission of photons. The measurements were compared to Monte Carlo simulations, using the FLUKA code. The simulation predictions are in good agreement with the GEMPix results. Future plans with respect to applications in hadron therapy are discussed.

In this paper we present irradiation measurements performed to select a transparent anode substrate that best meets the requirements of an optical readout for a novel detector, the LaGEMPix. The modification of the optical properties of the material due to proton irradiation were studied in soda-lime, fused quartz and fused silica glasses coated with an Indium Tin Oxide layer. The irradiations were performed using the research Beam Transfer Line (BTL) of the IBA Cyclone 18 MeV cyclotron of the Bern University Hospital (Inselspital). We recorded visible scintillation light generated by proton irradiation in the soda-lime and fused quartz samples. We also investigated the darkening of these three glasses and observed radiation-induced colour centres in the soda-lime glass sample. The optical transmission spectra of the samples were measured before and after irradiation. Reductions of 45%, 1% and 0.4% were observed for soda-lime glass, fused quartz and fused silica, respectively (with an associated error of 0.25%). We conclude that the best option for our specific application is the fused silica substrate, which will be the transparent anode for the next generation of the LaGEMPix detector.

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