We develop a new approach for assessing magnetic properties of submagnetic microparticles and cells, magnetophoretic trajectory tracking magnetometry (MTTM), that employs recording of long 2D trajectories of particle motion in a slot fluid channel caused by the action of crossed gravitational and magnetic forces. The studies are focused on the development of theoretical backgrounds of the method and evaluation of its uncertainty caused by the mutual hydrodynamic entrainment of moving particles. Computerized equipment implementing MTTM technique is described and its performance is illustrated. According to our studies, the new technique can serve a reliable experimental method with analytical qualities.
We investigate the magnetically driven motion in suspensions of paramagnetic particles. Our object is diluted deoxygenated whole blood with paramagnetic red blood cells (RBCs). We use direct observations in a closed vertical Hele-Shaw channel, and a well-defined magnetic force field applied horizontally in the channel plane. At very low cell concentrations, we register single-particle motion mode, track individual cells and determine their hydrodynamic and magnetic characteristics. Above 0.2 volume percent concentration, we observe local swirls and a global transient quasi-periodic vortex structure, intensifying with increasing cell concentration, but surprisingly this does not influence the time and purity of the magnetic extraction of RBCs. Our observations shed light on the behavioral complexity of magnetically driven submagnetic suspensions, an important issue for the emerging microfluidic technology of direct magnetic cell separation and intriguing for the mechanics of particulate soft matter.
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