Drawing of blood into a citrate-phosphate-dextrose (CPD) solution with a reduced
citrate concentration has been shown to improve the maintenance of coagulation
factor VIII (F VIII) in plasma and to give possibilities to improve erythrocyte
preservation. We studied the quality of plasma obtained from whole blood
drawn under continuous mixing into CPD in which the citrate concentration was
reduced by 50% (0.5CPD). The blood was stored at room temperature for 8 h
before component preparation. We confirmed improved stability of F Vili by
0.5CPD. We found no clinically significant changes in inhibitors to the coagulation
and kallikrein systems, and no signs of activation of these systems, during
the 8-hour holding time. In control blood drawn into CPD, F Vili and coagulation
factor IX decreased by 0.09 IU/ml (8%) and 0.07 U/ml (7%), respectively,
otherwise we found no significant differences between 0.5CPD plasma and CPD
plasma.
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