An electrochemical method to synthesize the core macrolactam of diazonamides is described. Large ring-forming dehydrogenation is initiated by anodic oxidation at a graphite surface. The reaction requires no tailoring of the substrate and occurs at ambient temperature in aqueous DMF in an undivided cell open to air. This unique chemistry has enabled a concise, scalable preparation of DZ-2384; a refined analog of diazonamide A slated for clinical development as a cancer therapeutic.
The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.
In this paper, the study of a non-Newtonian material when it is dragged through the narrow region between two co-rotating rolls is carried out. The conservation of mass and momentum equations based on lubrication theory are nondimensionalized and solved for the velocity and pressure fields using the perturbation technique. By considering the influence of the material parameter, the dimensionless leave-off distance in the calendering process is determined. The leave-off distance is expressed in terms of eigen value problem. Quantities of engineering interest like maximum pressure, the roll-separating force, and the power transmitted to the fluid by rolls are calculated. It is observed that the material parameter has great influence on detachment point, velocity, and pressure distribution, which are useful for the calendering process.
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