A basal mixed ration supplying 36 mg of Zn/kg of dry matter (DM) was supplemented with 1 of 4 concentrates differing in level and form of dietary Zn. The concentrates were fed at 2 kg/cow per day and contained 300 mg of Zn/kg (to supply the total recommended level, according to NRC (2001); R) or 60 mg of Zn/kg (to supply 0.66 of the total recommended level; L), either supplemented as ZnO (I) or organically chelated Zn (O). Forty-four Holstein-Friesian dairy cows (12 primiparous and 32 multiparous), on average 31 d (SD +/- 11.4) into lactation, were allocated to 1 of the 4 treatments. All cows remained on the treatment for 14 wk. The data was analyzed by ANOVA as a 2 x 2 factorial design. Dry matter intake averaged 23.5 kg/d and did not differ between treatments. Cows supplemented with organically chelated Zn at the recommended level of inclusion (RO) had a higher milk yield (37.6 kg/d) than those fed inorganic Zn at the recommended level (RI; 35.2 kg/d) or organically chelated Zn at the low level (LO; 35.2 kg/d), but was not different from those fed inorganic Zn at the low level (LI; 36.0 kg/d). Milk composition was unaffected by dietary treatment. Animals that received the low level of Zn (LI and LO) had higher somatic cell counts [3.97 and 3.93 versus 4.35 and 4.55 (log(e)) for RI, RO, LI, and LO, respectively] and milk amyloid A levels than those receiving the recommended levels (RO and RI). There was no effect of treatment on body condition score, body weight, or locomotion score. Hoof hardness improved over the duration of the study but there were no differences between treatments. Similarly, blood plasma mineral levels for Zn, Cu, Mo, and Fe were not affected by treatment, whereas there was a trend for increased ceruloplasmin levels in cows receiving the recommended compared with the low level of Zn, but there was no effect of mineral form. There was also no effect of treatment on superoxide dismutase activity or blood hematology. It is concluded that supplementing Zn at the recommended level reduced somatic cell counts and milk amyloid A levels, whereas supplementation in an organic form at the recommended level also increased milk yield.
The objectives of the study were to determine whether supplementation of pregnant ewes with long-chain (n-3) fatty acids present in fish oil, in combination with dietary vitamin E, would alter neonatal behavior in sheep. Twin- (n=36) and triplet- (n=12) bearing ewes were allocated at d 103 of gestation to 1 of 4 dietary treatments containing 1 of 2 fat sources [Megalac, a calcium soap of palm fatty acid distillate or a fish oil mixture, high in 20:5(n-3) and 22:6(n-3)] and 1 of 2 dietary vitamin E concentrations (50 or 500 mg/kg) in a 2 x 2 factorial design. Feeding fish oil increased gestation length by 2 d and increased the proportion of 22:6(n-3) within neonatal plasma by 5.1-fold and brain by 10%, whereas brain 20:5(n-3) was increased 5-fold. Supranutritional dietary vitamin E concentrations decreased the latency of lambs to stand in ewes fed fish oil but not Megalac, whereas latency to suckle was decreased from 43 to 34 min by fish oil supplementation. Supplementation with fish oil also substantially decreased the secretion rate (mL/h) of colostrum and the yield (g/h) of fat and protein. We conclude that supplementation of ewes with fish oil decreases the latency to suckle, increases gestation length and the 22:6(n-3):20:4(n-6) ratio in the neonatal brain, and may improve lamb survival rate. However, further work is required to determine how to mitigate the negative effects of fish oil on colostrum production.
The present study investigated the effect of maternal vitamin E and fatty acid supplementation on lamb antioxidant status. Forty-eight ewes were fed one of four concentrate diets supplemented with a basal (50 mg/kg) or supranutritional (500 mg/kg) level of vitamin E plus a source of either saturated fat (Megalac w ; Volac Ltd, Royston, Hertfordshire, UK) or long-chain PUFA (fish oil) from 6 weeks prepartum until 4 weeks postpartum. Blood samples were taken from ewes and lambs at intervals throughout the experiment and, at parturition, muscle, brain and blood samples were obtained from twelve lambs (three per treatment). Colostrum and milk samples were obtained at 12 h and 21 d after parturition, respectively. Supranutritional vitamin E supplementation of the ewe significantly increased concentrations of vitamin E in neonatal lamb tissues although plasma concentrations were undetectable. A significant increase in lamb birth weight resulted from increasing the dietary vitamin E supply to the ewe. Furthermore, maternal plasma, colostrum and milk vitamin E concentrations were increased by vitamin E supplementation, as were lamb plasma concentrations at 14 d of age. Neonatal vitamin E status was not significantly affected by fat source although plasma vitamin E concentrations in both ewes and suckling lambs were reduced by fish oil supplementation of the ewe. Fish oil supplementation reduced vitamin E concentrations in colostrum and milk and the activity of glutathione peroxidase in suckling lambs. The data suggest that the vitamin E status of the neonatal and suckling lamb may be manipulated by vitamin E supplementation of the ewe during pregnancy and lactation.
Supplementation of pregnant ewes with long-chain n-3 polyunsaturated fatty acids (PUFA) demonstrably improves indicators of neonatal lamb vigour, potentially improving the number of lambs reared per ewe. The present study investigated the effect of supplementing ewes with fish oil and vitamin E (a-tocopherol acetate) throughout both pregnancy and lactation on the performance of lactating ewes and sucking lambs. Forty-eight ewes were supplemented with one of four concentrates containing either Megalac or fish oil plus a basal (50 mg/kg) or supranutritional (500 mg/kg) concentration of vitamin E from 6 weeks pre-partum until 4 weeks post partum in a two-by-two factorial randomised-block design. All concentrates were formulated to contain approximately 60 g/kg supplemental fatty acids. Ewes were housed, penned on sawdust and offered straw ad libitum. Blood samples were taken from ewes and lambs at intervals throughout the experiment and milk samples were obtained at 21 days into lactation. There was no notable effect of dietary vitamin E concentration upon ewe or lamb performance. Ewe dry-matter (DM) intake and yield were unaffected by dietary treatment, although ewes fed fish oil lost less weight during lactation (21.88 kg compared with 23.97 kg for Megalac-supplemented ewes; P , 0.01). Milk fat concentrations (67.3 g/kg compared with 91.8 g/kg; P , 0.01) and yields (6.65 g/h v. 9.26 g/h; P , 0.01) were reduced in ewes fed fish oil and these decreases were associated with lower litter-growth rates (0.49 g/day compared with 0.54 g/day; P , 0.05). Milk protein yield was increased by fish oil supplementation (3.82 g/h) compared with Megalac supplementation (3.28 g/h; P , 0.05); moreover, there was an interaction between fat source and vitamin E concentration in that both protein concentration and yield were significantly lower in milk from ewes fed treatment with Megalac 1 basal vitamin E (MB) compared with the other three treatments. Fish oil supplementation increased the concentrations of C 18:1 trans-, cis-9, trans-11 conjugated linoleic acid (CLA), C 20:5 (n-3) and C 22:6 (n-3) within ewe plasma, milk and lamb plasma. The mechanisms by which fish oil supplementation affects milk composition warrants further investigation.
The prevalence and severity of gastric ulcers were investigated in a sample of 50 slaughter pigs from each of 16 commercial farms in the uk. The mean prevalence of ulcers was 19.1 per cent and the mean (se) severity score on the 16 farms was 2.2 (0.15) on a scale from 0 (normal) to 6 (severe). Multivariate regression analysis showed that the type of lying surface provided for the pigs during the finishing phase was the most important factor associated with the occurrence of gastric ulcers in the farms studied. Finisher pigs housed on slatted floors had a significantly higher mean ulcer severity score (P<0.001) than pigs housed on solid concrete floors, which had a significantly higher score (P<0.01) than pigs housed on straw bedding. Feeding a pelleted finisher ration was also associated with significant increase in ulcer severity (P<0.01) compared with feeding an unpelleted ration, but was of less importance than the type of floor. The detrimental influence of feeding pellets was ameliorated by the provision of straw bedding.
An experiment was conducted to quantify the effects of 3 nutritionally complete (similar protein and energy) corn-based diets that contained different dietary protein concentrates (potato-CP 76%, fish-CP 66%, or a mixture of soy proteins, soybean meal-CP 48%, and full-fat soy-CP 36%) on the incidence of spontaneously occurring subclinical necrotic enteritis (NE) in broiler chickens. A total of 1,260 birds were placed into 18 solid floor pens (70 birds per pen) and fed 1 of the 3 experimental diets from 15 to 31 d of age. The weight gains and feed intakes of the birds fed the potato- and fish-based diets were lower (P < 0.001) than those of the birds fed the soy-based diets. Weight gain:feed intake ratio and mortality rate were not affected (P > 0.05) by dietary treatment The birds fed the potato-based diets had a higher incidence of necrotic lesions in the duodenum (P < 0.001) and proximal jejunum (P < 0.01) than those fed the soy-based diets. The chickens fed the potato-based diet had a higher (P < 0.001) proportion of moderate to severe duodenal and distal ileal hemorrhages and liver lesions than the birds fed the soy-based diet. There was also a higher (P < 0.05) level of serum antibodies for Clostridium perfringens alpha toxin in birds fed the potato-based diet compared with the other 2 diets. The birds fed the fish-based diet had a similar (P > 0.05) incidence of subclinical NE in comparison to the birds fed the soy-based diet, although there was a higher incidence of intestinal hemorrhagic lesions. The differences in incidence of subclinical NE were not consistent with the relatively small differences in amino acid content between the diets or in the contents of nonstarch polysaccharides. However, the potato protein-based diet had higher trypsin inhibitor activity and a lower lipid content that could have contributed to the increased incidence of subclinical NE.
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