1 Eight tetracycline drugs were tested for inhibitory effect on phytohaemagglutinin (PHA) stimulated growth (measured by [3H]-TdR uptake) of peripheral blood mononuclear cells: at least 26 normal subjects were tested with each drug. 2 Doxycycline reduced DNA synthesis appreciably at concentrations within and just above the therapeutic range of blood levels: it was the most potent inhibitor, but demeclocycine, methacycline and minocycline had similar, if less potent, effects. Tetracycline, oxytetracycine, chlortetracycline and clomocycline did not inhibit DNA synthesis of 3-day cultures even at concentrations five to ten times greater than the therapeutic blood level. 3 Volume spectroscopy measurements showed that none of the eight tetracycline drugs interfered with the recruitment of cells into GI-phase growth of the first cell cycle after PHA stimulation.
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