We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen C. albicans. Our system entitled Candescence automatically detects C. albicans cells from Differential Image Contrast microscopy, and labels each detected cell with one of nine vegetative, mating-competent or filamentous morphologies. The software is based upon a fully convolutional one-stage object detector and exploits a novel cumulative curriculum-based learning strategy that stratifies our images by difficulty from simple vegetative forms to more complex filamentous architectures. Candescence achieves very good performance on this difficult learning set which has substantial intermixing between the predicted classes. To capture the essence of each C. albicans morphology, we develop models using generative adversarial networks and identify subcomponents of the latent space which control technical variables, developmental trajectories or morphological switches. We envision Candescence as a community meeting point for quantitative explorations of C. albicans morphology.
Supervised Fractional Eigenfaces (SFE) is an extension of Principal Component Analysis (PCA), which uses the fractional covariance matrix, class label information, and nonlinear data transformation to extract discriminant features. The proposed method combines techniques of two state-of-theart feature extractors: Fractional Eigenfaces and Dual Supervised PCA. Supervised Fractional Eigenfaces was evaluated in three known face datasets and it achieved significant smaller recognition error.
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