The pharmacological selectivity imposed by the micro-organisms enabled the emergence of new perspectives in the research field of natural products, in which the monoterpenic phytoconstituents, especially the 7-hydroxycitronellal (7- OH) present antimicrobial activity. Therefore, this study assessed the in silico antimicrobial and toxicological activity of the monoterpene 7-OH. The product was solubilized in tween 80 and dimethylsulfoxide (DMSO). Later it was diluted in sterile distilled water up to the concentration of 2048µg/mL. The minimum inhibitory concentration (MIC) of the product was determined by microdilution in doubly concentrated brain heart infusion (BHI) medium. The minimum bactericidal concentration (MBC) was determined by the depletion technique in nutrient agar (NA) with aliquots of 10µL of the MIC, MIC × 2 and MIC × 4. The MIC and the MBC of the 7-OH was 64µg/mL for S. aureus (ATCC 6538). However, for S. epidermides (LPM 35), S. aureus (LPM 45) and S. aureus (LPM 55), were 512 and 1024µg/mL respectively. In the in silico toxicological analysis the absence of mutagenic, tumorigenic effects and damage to the reproductive system were observed. Therefore, the 7-OH is bactericidal for the strains used in this study and presents a theoretical low oral toxicity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.