To examine the role of reactive oxygen species (ROS) in stress-induced gastric ulceration and possible protective effect of proton pump inhibitor omeprazole male adult rats were immobilized for 9 hours. Phagocyte-derived ROS were measured using the chemiluminescence method in whole blood obtained at start and after 3,6, and 9 hours of immobilization. As indirect sign of gastric mucosal damage faeces were examined after 3 and 6 hours for blood spots presence and after 9 hours the animals were killed and stomachs were examined.Stress resulted in a gigantic increase of ROS in immobilized animals both without and with omeprazole. Blood spots were not found after 3 hours of immobilization. After 6 hours, massive presence of blood spots was found in immobilized animals in contrast to minimal presence (P
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