were compared to respective baseline values using a paired t-test. Results: The full cohort consisted of 311 subjects, with 210 subjects in the ≥ 4months and 167 subjects in the ≥ 6months persistence groups. For all subjects, average age was 49.7 and subjects were predominantly white (77.5%) and female (83.0%). Average BMI was 40.7 kg/m2, and weight was 114.8 kg. At baseline, 74.9%, 19.9% and 5.1% of subjects had normoglycemia, prediabetes, and diabetes, respectively. Average baseline values for HbA1c and blood pressure were 5.8% and 127/77 mmHg. There was a significant change in body weight 6 months after initiation of treatment in persistent subjects (≥ 6months:-8.1 kg, p< 0.001). Weight loss was also significant for subjects persistent on treatment for ≥ 4months (-6.9 kg, p< 0.001) and in all subjects, regardless of persistence (-7.5 kg, p-value< 0.001). Percentage change in body weight from baseline for the ≥ 6months group was-7.1%, with 63.4% and 35.2% of subjects having lost ≥ 5% and > 10% body weight, respectively. Overall percentage change in body weight was also observed in the ≥ 4months group (-6.2%) and in all subjects (-6.6%). For the ≥ 6months treatment group, there was a statistically significant change in HbA1c (-0.35%, p< 0.001) and SBP (-3.0 mmHg, p< 0.01), but not DBP (0.1 mmHg, p= 0.90). ConClusions: In a real-world setting, liraglutide 3.0 mg, when combined with diet and exercise, was associated with clinically meaningful weight loss and with improvements in cardiometabolic markers. PSY11 Model-BaSed evaluation of the efficacY and SafetY of BuroSuMaB, a fullY huMan anti-fGf23 Monoclonal antiBodY, in adoleScent X-linked hYPoPhoSPhateMia (Xlh)
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