Rationale: Limited data on the epidemiology of acute respiratory distress syndrome (ARDS) using a standardized screening program exist.Objectives: To describe the population-based incidence of hypoxemic respiratory failure and ARDS using a prospective standardized screening protocol; and to describe the mechanical ventilation practice and the mechanical power and examine their association with 28-day and 3-year survival outcomes.Methods: A prospective standardized screening program for ARDS, as a quality improvement initiative, was initiated at four adult intensive care units over a 27-month period. An ancillary analysis of this observational cohort was performed. Patients requiring mechanical ventilation for ≥24 hours underwent prospective and consecutive screening using standardized ventilator settings. Patient physiological data and outcomes were collected prospectively through an electronic clinical-information system and retrospectively analyzed to apply Berlin criteria.Results: Screened were 7,944 patients, among which 986 (12.4%) had hypoxemic respiratory failure (arterial oxygen tension to inspired fraction of oxygen ratio ≤300), and 731 (9.2%) met criteria for ARDS. Age-adjusted incidence of hypoxemic respiratory failure and ARDS were 37.7 and 27.6 cases per 100,000 person-years, respectively. Patients sustaining the diagnosis of ARDS had a hospital mortality of 26.5% for mild, 31.8% for moderate, and 60.0% for severe ARDS and a 3-year mortality of 43.5% for mild, 46.9% for moderate, and 71.1% for severe ARDS. Mechanical power >22 J/min was associated with increased 28-day hospital and 3-year mortality. Determinants of mechanical power associated with lower 28-day hospital and 3-year survival included plateau pressure >30 cm H2O and driving pressure >15 cm H2O, but not tidal volumes >8 ml/kg of predicted body weight.Conclusions: Using standardized screening, a large proportion of patients with hypoxemic respiratory failure met criteria for ARDS. Increasing ARDS severity was associated with increased 28-day hospital and 3-year mortality. Increased mechanical power was associated with increased mortality. Potentially modifiable determinants of mechanical power associated with lower survival included plateau pressure and driving pressure.

Forty-eight pigs (barrows:gilts, 1:1) with an average initial weight of 9.4 kg were used in a 2 x 2 factorial experiment to determine the influence of dietary phytase (0 or 1,500 phytase units/kg) and zinc (0 or 100 mg/kg) supplementation of a corn-soybean meal diet on the utilization of P, Ca, Cu, Mg, Mn, and Zn. After a 21-d growth experiment, feed was withheld for 24 h and blood was collected from the anterior vena cava of all pigs for plasma mineral analyses. Twenty-four barrows from the growth experiment were then placed in metabolism cages and used in an 8-d mineral balance study. All pigs were maintained on their previous diet. Growth rate was fastest (P < .05) and feed efficiency was highest (P < .05) for pigs fed phytase-supplemented diets. Feed intake was unaffected (P > .05) by dietary treatment. Plasma P (P < .01) and Mg (P < .05) concentrations increased with phytase addition. Plasma Zn concentration increased (P < .05) when phytase was added to the diet containing no supplemental Zn, but plasma Zn concentration was not affected (P > .05) by phytase when the diet was supplemented with 100 mg of Zn/kg. Apparent Ca, P, and Cu balance were improved (P < .05) with phytase addition; however, Cu balance was reduced (P < .05) by Zn supplementation. Zinc balance was increased (P < .05) with supplemental zinc and phytase in the diet. These results indicate that the growth-promoting effect of phytase may be due to an overall increase in the availability of minerals.

A 6‐yr field experiment was conducted to determine the effects of liquid and solid dairy (Bos taurus) manure applications on a Crosby silt loam (Aerie Ochraqualfs) soil cropped to corn (Zea mays L.). Liquid manure at rates of 112, 224, and 336 Mg ha−1 and solid manure at rates of 34, 67, and 101 Mg ha−1 were spread annually for 5 yr. No manure was applied the 6th yr, but the soil was cropped to determine residual nutrient effects. Check and inorganic fertilizer treatments were also included in the study. Manure addition increased corn yields when compared to the check (no fertilizer). There were variable weather conditions and nutrient concentrations of the manure sources, and the manure application rates were relatively high. Corn yields were as great or greater from plots supplied with manure and manure slurries as those supplied with commercial fertilizer. Over the 5 yr of manure application, the 224 Mg ha−1 rate of liquid manure and the 67 Mg ha− rate of solid manure results in maximum corn yields that were 1% higher than commercial fertilizer. Accumulations of nutrients in the soil from high liquid manure application rates (224 and 336 Mg ha−1) increased corn yields during the residual cropping year. Corn leaf N and P concentrations tended to reflect N and P rates applied with the manures and the fertilizer treatment compared to the check, but not consistently each year. Source of manure had little affect on corn leaf composition. Soil P, K, and Na increased with each additional year of manure application and tended to increase with higher application rates. Extractable P accumulated in the upper profile of soil, whereas exchangeable K and Na increased at lower depths in the soil profile, especially with the highest manure application rates. Based on this study, both solid and liquid dairy manures are valuable sources of nutrients for corn production; however, they are less efficient than commercial fertilizers when comparing equivalent nutrient levels and when they are applied to the soil surface. Excessive application of either manure source causes potential for considerable groundwater pollution.

Randomized complete block design field experiments were conducted to determine the effects of rates and methods of liquid swine manure application on volatile NH3‐N losses from cropland. In addition, a greenhouse study was conducted to determine the effect of wind on the rate of NH3‐N volatilization from soil and the accuracy of NH3‐N loss measurements under field conditions. A partially closed system was utilized to directly collect volatilized NH3‐N from microplots.The NH3‐N collection system did not accurately estimate volatile N losses when windy conditions existed as often encountered in the field. Using direct measurement of NH4+‐N in waste before and after exposure to the atmosphere to correct for the low estimates of NH3‐N loss under field conditions, an average of 48.1% of the volatilized N was collected under greenhouse conditions with relatively constant temperature and wind.The rate of NH3‐N loss from manure increased with increasing temperature and air movement. The proportions of the applied NH4+‐N lost as NH3‐N during a 3.5‐day sampling period in the spring from swine manure (pH 6.4) applied to soil (pH 6.4) and corrected for the effect of wind were: 14.0%, 12.2%, and 11.2% for the 90, 135 and 180 metric ton/ha, respectively, of surface applied liquid swine manure; 2.5% for both the 90 and 180 metric ton rates, respectively, of injected liquid swine manure; 14.7% for surface applied urea fertilizer (168 kg N/ha); and 65.8% of the applied NH4+‐N from swine manure surface applied (90 metric tons/ha) on a plastic liner. Fresh swine manure (pH 7.8) surface applied at the rate of 135 metric tons/ha on greenhouse loam soil (pH 7.0) lost 82.5% of the applied NH4+‐N in an 8‐day sampling period.

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Ammonia (NH3) emission from a grow‐finish swine (Sus scrofa) building with an underfloor manure storage pit was evaluated during warm weather from 26 June to 25 September. Average daily mean (ADM, covering all measurement days) outdoor temperature was 21.8°C. Ammonia concentrations, ventilation rates, and temperatures were continuously measured or recorded and 88 d of reliable data were obtained. Air samples were taken at wall and pit exhaust fans and in the pit headspace. The NH3 concentrations were monitored on‐site with a chemiluminescence NH3 analyzer. Ventilation rates were calculated based on operation of five wall fans, four pit fans, and the fan static pressure. The NH3 emission rates were calculated by multiplying simultaneously measured NH3 concentrations and ventilation rates of wall and pit exhaust fans. The ADM of building NH3 concentration (mean concentration of all sampling locations) was 3.9 mg m−1. The ADM building NH, emission (sum of the emissions from all ventilation fans) was 11.2 kg d−1, equivalent to 145 g d−1 per AU (animal unit = 500 kg animal weight). The ADM emission per AU was higher than other reported values, probably due to warmer temperatures and higher ventilation rates. The building NH3 concentrations were inversely proportional to the indoor temperatures (r = −0.66) and ventilation rates (r = −0.59) and correlated well to total pig weight (r = 0.49). The building NH3 emission rates were correlated to total pig weights (r = 0.52) and ventilation rates (r = 0.41) and were not well correlated to indoor temperatures (r = 0.12).

A 3‐year field experiment was conducted to study the agronomic effects of methods and rates of liquid swine manure application to Brookston‐Crosby silt loam soil (fine, mixed mesic Aeric Ochraqualfs) cropped to corn (Zea mays L.). Swine manure (5.2–6.6% dry matter) from an anaerobic pit was applied to soil annually at 90, 135, and 180 t/ha by injection (30 cm below soil surface) and broadcast (surface) methods. These three rates provided averages of 428, 643, and 857 kg N/ha; 133, 200, and 266 kg P/ha; and 155, 232, and 310 kg K/ha per year; respectively. Check and inorganic fertilizer (168 kg N/ha, 56 kg P/ha, and 112 kg K/ha) treatments were also studied.The injection method of liquid manure application increased corn grain yield an average of 2,130 kg/ha each year, compared with the broadcast method at similar rates of application. Injection of swine manure was associated with higher corn‐leaf N levels the first year; corn‐leaf N, P, and K levels the second year; and corn‐leaf N and K the third year of the study when compared with corn leaves from the broadcast method. Rate of manure application had little influence on corn‐leaf analyses, and inconsistent effects on corn yield.Nutrient loadings of the soil from liquid manure applications were in excess of crop requirements, as evidenced by nutrient accumulations, particularly P and K, in the soil. Increases in soil nutrient levels at different depths in the profile reflected the initial placement of the manure by application methods (broadcast vs. injection). Volatile losses of NH3‐N from surface‐applied liquid manure were reflected in lower corn yield response, lower corn‐leaf N content, and lower soil NH4+ and NO3− levels when comparing these parameters with the injection treatment. Application of liquid swine manure by injection at the 90 t/ha rate increased corn grain yield 14% above that from the inorganic fertilizer treatment.

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