Short oral presentation abstracts (Lachmann et al., 2011). However, in our observation, the brain stem of spina bifida fetuses is characterized by kinking and thinning, rather than thickening. We examined the biometry and utility of these first trimester spina bifida markers in our population. Methods: Mid-sagittal facial images obtained at nuchal translucency screening between 11-0/7 and 13-6/7 weeks gestation were digitally stored. Normal (n = 500) and randomly interspersed spina bifida cases (n = 10) were analyzed by three blinded examiners. The BS was measured from the posterior border of the sphenoid bone to the anterior border of the fourth ventricle, and the BSOB from the latter to the anterior border of occipital bone, and adjusted for crown-rump length (CRL). Normality of distribution was confirmed with the Kolmogorov-Smirnov test, and means of spina bifida group and normals were compared by t-test. Results: BS diameter increased with CRL (R 2 = 0.14; P < 0.0001), whereas BSOB and BS/BSOB ratio decreased with CRL (R 2 = 0.168; P < 0.0001). BS diameter was significantly smaller in spina bifida fetuses (P < 0.0001; 4/10 cases below 5 th %ile, none above 95%ile), and BS/BSOB ratio was significantly higher in the spina bifida group (P < 0.002; 6/10 cases above 95 th %ile). With a 95% specificity, the above cutoff limits would yield a 40% and 60% sensitivity for SB detection, respectively. Conclusions: In our study population, spina bifida is associated with smaller brain stem diameters in comparison to normal first trimester fetuses. This would yield lower detection rates in screening with the BS/BSOB ratio than previously reported.
Oral communication abstractsfetuses with LCDH despite the often concurrent hypoplasia of left heart structures. This decrease in ventricular size is most likely the anatomical explanation for the observed increase in strain values in the left ventricular free wall.
OC07.03Cardiac assessment in fetuses with right-sided congenital diaphragmatic hernia (RCDH): a case-controlled study Objectives: To evaluate the outcome in cases of congenital diaphragmatic hernia (CDH) associated with heart defect. Methods: We reviewed data from all infants born in our Fetal Center between January 2000 and November 2012 that had the diagnosis of CDH. Postnatal outcomes in cases with isolated CDH were compared to those with iCDH and associated cardiac defect. Further analysis was performed considering the presence of major or minor cardiac anomaly. Patients with chromosomal abnormalities were excluded. Results: A total of 152 newborns with CDH were identified. 118 newborns had isolated CDH while 34 newborns had CDH with associated cardiac defect (without chromosomal abnormalities). Minor and major cardiac anomalies were diagnosed in 26 (76.4%) and 8 (23.5%) newborns, respectively. There was no significant difference in the frequency of pulmonary hypertension between newborns with isolated CDH [56.6%)] and those with CDH and heart defect (62.9%; P = 0.55) and needing for ECMO (33.8% vs. 29.4%; P = 0.77). Infants with isolated CDH had a higher survival rate than those with associated cardiac defect (77.1% vs. 55.8; P = 0.03), since the survival rate was lower based on the severity of the cardiac anomaly (major anomaly −25.0% vs. minor anomaly −61.5%; P = 0.04). Conclusions: In general, heart defect associated with CDH did not result in worse outcomes, despite the fact that the presence of a major heart defect was associated with a higher occurrence of pulmonary hypertension.
OC07.05 A comparison of myocardial velocity information derived by pulsed and color Doppler techniques
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