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This study explains the relationship between friction coefficient and pressure change at a range of Reynolds (21,056-28,574) and (0-1.4) solid loading ratio of two-phase flow (gas-solid) inside a circular copper pipe by using laboratory apparatus and solving the equations mathematically. An experimentally relationship of friction coefficient and pressure change with Reynolds number and flow velocity obtained also the relationship between the Solid loading ratio with friction coefficient and pressure change has been done for a Limit range of Reynolds number. It was noticed that the increase in friction coefficient and pressure change for two-phase flow was occurred when solid loading ratio increased. Also the relationship between pressure change and Reynolds number was direct proportion while the relationship between friction coefficient and Reynolds Number was inversely related.