High-density lipoproteins in vitro captured by resident liver macrophages (Kupffer cells) are rapidly degraded in secondary lysosomes, but their protein components are not hydrolyzed completely. Immunological properties of apolipoprotein A-I secreted back to the incubation medium are completely preserved. This process is accompanied by enhanced production of apolipoprotein E by Kupffer cells and is markedly promoted by hydrocortisone.
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