We report a case of congenital varicella syndrome after maternal infection during the 10th week of pregnancy. None of the typical abnormalities were manifested at birth; however, the child experienced neonatal tonic convulsions that evolved to refractory focal epilepsy with adversive, complex partial, and secondarily generalized seizures. At the age of 5 years, after a prolonged generalized seizure following cranial trauma, cranial computed tomography (CT) was performed. It led to the misdiagnosis of post-traumatic intracerebral hemorrhage. Afterwards, because of persistent seizures and developmental delay with mild or slight intellectual deficit, the next CT and magnetic resonance imaging (MRI) investigation at 8 years of age disclosed massive malformation of the left cerebral hemisphere. The serologic evidence of varicella-zoster virus-specific IgG antibodies without a history of varicella disease after birth and maternal infection during early pregnancy were crucial to diagnosing the rare syndrome of congenital varicella consisting of isolated brain damage.
The antiphytoviral activity of 1-morpholinomethyl-tetrahydro-2(1H)-pyrimidinone (DD13) in a test system including protoplast cultures, surviving tissues and greenhouse plants was examined. The inhibitory effect was quantitatively investigated by immunofluorescence and enzyme linked immunosorbent assay. The antiviral action in vitro was 96%. The first 6 h after inoculation was the most sensitive period of the tomato mosaic virus (ToMV) reproduction cycle. DD13 possessed a protective effect in 97-100% plants infected with ToMV and cucumber mosaic virus (CMV).
Aus den Aminen (I) und den Sulfochloriden (II) werden die Sulfonanilide (III) hergestellt, die zu (IV) reduziert und anschließend durch Diazotierung und Cyclisierung in (V) übergeführt werden.
Some N-mono-2a-e and N,N'-bis(aminomethy1) derivatives 3a-b of tetrahydro-2-( 1H)-pynmidinone l a and tetrahydro-2( 1H)-pyrimidinethione l e are obtained by the Munnich reaction of l a or l e with formaldehyde and secondary amines. The compounds show a marked antiviral activity. Struktur und Eigenschaften cydicher Polymethylen-Harnstoffe, 3. Mitt.: Synthese und biologische Aktivitat von einigen Tetrahydro-2(1H)-Pyrimidinon-Mannich-Basen Es wurden N-mono-2a-e und N,N'-bis-aminomethyl-Derivate 3a-b von Tetrahydro-2-( 1H)-pyrimidinon la und Tetrahydro-2(1H)-pyrimidinthion l e durch Munnich Reaktion von l a oder l e mit 0365-6233/82/0M)&00509 $ 02.50/0 0 Verlag Chemie GmbH. Weinheim 1982
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