The current study was performed to estimate the influence of topical application of 10% of Plantago major leaves extract (PMLE) on a healing process of contaminated excisional wound in local breed rabbits. Twenty adult local breed male rabbits were used. After the animals have generally anesthetized, two 2×2 cm full thickness wounds were created in thoracic region on right and left side (1wound/side) for each animal. Wounds on right side of animal were treated by topical irrigation with normal saline/daily, this consider as control (group A). While, left side wounds were treated by topical application of 10% PMLE ointment (once/day) that consider as treated (group B) dressing was used after each treatment for both groups. Wound healing was evaluated through macroscopic examination, wound contraction rate (WCR) assessment and histopathological examination. Results of macroscopic examination confirmed that PMLE has a role in acceleration healing when compared to control group. These outcomes were parallel with WCR results in which reflect the mean rate of wound contraction on days 7 th , 14 th , and 21 st in PMLE-treated group was significantly higher (P<0.001) than that of the normal salinetreated group. Histopathological examination results confirmed early increased in new blood vessels formation, fibroblasts proliferation, marked collagen precipitation and early epithelization in group PMLE compared to group A. This study confirmed that topical application of 10% of PMLE (once/a day) has an effective role in accelerate contaminated wound healing through its phenolic and flavonoid contents as recorded by high performance liquid chromatography (HPLC) assessment that act as antioxidant and antiinflammatory substance which help in the enhancement the WCR through encourage early and additional fibroblast proliferation and angiogenesis when compared to control group.
This study has been done to evaluate the effect of transverse and oblique anastomosis on esophageal healing. Partial esophagectomy were performed on sixteen adult dogs, animals were divided into two equal groups ,in the group one a transverse anastomosis ,while in group two oblique anastomosis were done. Two layers of simple interrupted pattern were used to closed the anastomosis site, the first layer was oppose the mucosa and submucosa by simple interrupted suture with the knots tided inside the lumen and the second layer was appose muscularis and adventitia by simple interrupted suture using catgut (2.0). The results of histopathological and radiological were revealed that ,the healing of group two was faster than group one ,which manifested by collagen fiber formation with complete mucosal formation in a shorter time compared with group one. In addition to that the mean degree of stenosis was less in second group at 30 days post operation(14.24±0.21), in spite of no significance difference between two groups at the level of p≤ 0.05.
Objective: The experimental study was performed to assessment the influence of topical application of 10% of plantago lanceolata leaves extract (PLLE) in enhancement of contaminated excisional wound in 20 adult local breed rabbits. Methodology: Twenty adult local breed male rabbits were used in this experimental study. After animals anesthetized then twenty surgical excisional wound in diameter (2cm) were created on thoracic region (1wound\side). Rabbits were divided into control group in which wounds on right side were treated by irrigation with normal saline once \daily. Whereas, in treated group wounds on left side treated by topical application of 10% PLLE ointment (once\day). All wounds were dressing. The healing process was evaluated through macroscopic examination, wound contraction rate (WCR) and histopathological examination. Result: The presence study confirm there were significantly different at (P≤0.05) were registered between control and treated group along the time of study in which PMLE play accelerating role since it used.
The aim of this study was to estimate the changes in ventral hernia repairing in Iraqi bucks by using two biological matrixes derived from bovine (pericardium and urinary bladder matrix) through histopathological examination. All bucks right lower flank awas prepared surgically, sedation were done by using (2% Xylazine hydrochloride) at a dose of 0.2mg/kg intramuscular, and surgical site anesthetized through an inverted (L) shape local infiltration technique using lidocaine hydrochloride (2%) at a dose of 8mg/kg. Ventral abdominal hernias were induced in (24) bucks through elliptical resection of abdominal muscles to made hernia ring (6-8cm) with avoiding peritoneum perforation. After 30 days of operation bucks were divided into two equal groups. cellular Bovine pericardium group and cellular urinary bladder matrix group. In two groups hernias were treated with only replacement of acellular bovine pericardium and cellular urinary bladder matrix respectively which fixed with interrupted horizontal mattress 2cm far from hernia ring by Polypropylene (No.1) suture material. Histopathological biopsies were taken at 2nd, 8th and 16th week post treatment (4 bucks\ period). Both groups’ successes in reconstruction of large hernia in bucks through prevent recurrent or others post-operative complications. In addition the histopathological examination showed that the acellular urinary bladder matrix superior than acellular bovine pericardium matrix in enhance healing based on acellular urinary bladder matrix role in augment early initiation of inflammatory cells infiltration, fibroblast proliferation and marked collagen deposition, in addition to its early degradation, incorporation and remodeling.
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