HA and Hepascore cannot accurately stage hepatic fibrosis in this population. Locally derived, disease-specific cut-offs for HA gave the higher diagnostic efficiency observed. Although HA and Hepascore may be useful where the disease aetiology is known, particularly in established hepatitis C virus, the high cost of false positives and false negatives are such that neither a reliable enough to replace biopsy without substantial further characterization.
Acne induced by PUVA treatment Recently there has been a rapid development in the worldwide use of oral and topical methoxsalen (8-methoxypsoralen; 8-MOP) with long-wave ultraviolet light (UVA) for treating patients with psoriasis. This form of photochemotherapy is known as PUVA treatment, and is effective in clearing and maintaining a remission of psoriasis in most patients treated.1-3 It is currently being evaluated at various centres in the UK to define the indications for its use and to determine the short-and long-term side effects. Acute side effects such as erythema, nausea, pruritus, and dizziness, though rare, are well recognised.4 We report a hitherto unrecognised side effect of PUVA treatment: the development of an acneiform eruption in one of our patients.
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