We have developed an integrated microfluidic platform for producing 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.
The dependencies of creation–passivation processes of interface traps in irradiated n-channel metal-oxide-semiconductor transistors on the temperature and gate bias during annealing have been investigated. The experimental results, which are explained by the hydrogen–water (H–W) model, show the influence of both the annealing temperature and gate bias on these processes. The modelling of creation–passivation kinetics of interface traps, based on bimolecular theory and numerical analysis, is also performed. Numerical modelling shows that the H–W model can include the temperature and gate bias dependencies of creation of interface traps, latent interface trap buildup and the decrease of interface trap density.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.