Summary. Evidence for serological cross-reactions between To.xocara cants and related nematode parasites has been sought using sera from infecled mice and the immunodiagaoslic excretory/secretory (ES) antigen of T. canis larvae. Sera from mice experimentally infected with either T. cani.i. T, caii. T. ptcropodis, Toxascaris leonino or Ascaris suum were tested for the presence of antibodies to T. canis ES antigen by solid-phase radioimmunoassay (RIA) or enzyme-linked immunosorbent assay (ELISA) using anti-mouse IgG. 7". canis ES antigen was obtained from the medium used to culture T. canis larvae, this being the same source of antigen as has been used in a highly satisfactory immunodiagnostic lest for human toxocariasis (viscera! larva migrans). Sera from mice infected with cither A. .tui/m, T. cati or T. pteropodis showed definile cross-react ions with T. cam's ES antigen in one or other of the two essays used. No reaction between anti-r. teonina sera and T. canis ES antigen was demonstrated, although infection levels with this parasite were low in mice. Concerning biological activity of ES antigen, it is of some interest that mice hyperimmunised with 7". canis ES antigen in adjuvant were shown to be significantly resistant to infection by 7". canis.
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