to both the organ and the recipient at the time of transplant. Serum transaminases, histological changes of the liver and animal survival were assessed. Oxidative stress, inflammatory responses and hepatocellular damage were also quantified. Result: A significant survival benefit was not achieved when CD47mAb400 was administered to the donor alone. However, CD47mAb400 administration to both the donor and recipient increased animal survival after. The CD47mAb400 treated group showed lower serum transaminases, bilirubin, oxidative stress, TUNEL staining, caspase-3 activity and proinflammatory cytokine expression of TNF-a, IL-1b and IL-6. Conclusion: CD47 blockade with CD47mAb400 administered both to the donor and the recipient reduced liver graft IRI in a rat liver transplantation model. This may translate to decreased liver dysfunction and increased survival of liver transplant recipients.
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