Changes in heart rate and stroke volume after successive blockade of cardiac adreno- and cholinoceptors were examined on rats of different age. It was established that irrespective of animal age the heart rate remained unchanged under conditions of total adreno- and cholinergic blockade of the heart. Stroke volume under conditions of total adreno- and cholinergic blockade increased with age.
In the article there are given results of the evaluation of non-carcinogenic risks for the health of the child population residing in different areas (districts) of the city of Kazan with the aim of the subsequent comprehensive assessment of the pollutants in drinking water. Assessment of the risk for the human health was performed correspondingly to with the P 2.1.10.1920-04 for oral route of exposure in accordance to the chemical composition of drinking water with account for the standard and regional factors of the exposure. The results of the risk assessment under the consumption of drinking tap water by the child population with localized place of residence permit to reveal areas with a high level of health risk in the city. The screening assessment of carcinogenic risk due to the consumption of chemicals with drinking water revealed differences in regional and standard values of the exposure factors. This affects both on the value of the chronic average daily intake of chemical contaminants in drinking water and the level of risk under the consumption of drinking water by the child population.
Monitoring of atmospheric air in the city of Kazan was performed based on average annual concentrations of the Air Pollution Observation Stations (APOS) of three administrations: The Federal Budgetary Healthcare Institution �Center of Hygiene and Epidemiology in RT (Tatarstan)� (FBHI �H&E Center in RT�), Ministry of Environment and Natural Resources of RT (MEPNR of RT) and Federal State Budgetary Institution �Territorial Administration for Hydrometeorological and Environmental Monitoring in RT� (FSBI �TAHEM in RT�). Two Kazan districts with population size equal to one third of the city (the Vakhitovsky and the Sovetsky ones), where APOS of all three administrations were compactly located, were identified for the study. Control data differ in pollutants priority and quantitative estimation of certain pollutants. Non-carcinogenic risk evaluation results on chemical effluence with vehicle emissions had no discrepancies (unacceptably high total risk level in Vakhitovsky and Sovetsky city districts, HI was greater than 6.0); however, danger coefficients obtained from the data of the Federal State-Funded Healthcare Institution �Hygienic and Epidemiological Center in the Republic of Tatarstan� far exceed similar results of other agencies. Verification of the available sampling techniques and development of a single approach to analysis and evaluation of the environmental pollution by harmful substances are required for a consistent risk assessment by monitoring agencies.
The work presents the results of a study of the effectiveness of the use of an immunomodulating agent for the treatment of recurrent herpetic stomatitis in children with bronchial asthma.
The therapy of recurrent herpetic stomatitis was carried out in 67 children aged 1 to 16 years with bronchial asthma according to the scheme proposed by the authors using an immunomodulator. The immune status of patients before and after the therapy was assessed using the following indicators: the content of immunoglobulin (SIgA) in saliva, salivary lysozyme, an integrated indicator, the balance coefficient (Ksb).
The results of the study showed that after the therapy, the incidence rates of recurrent herpetic stomatitis improved, the state of local immunity approached the group of healthy children.
It is concluded that the proposed therapy for recurrent herpetic stomatitis in children with bronchial asthma gave a positive result and can be recommended for the treatment of this category of patients.
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