Our results confirm that antihypertensive monotherapy with the ACE inhibitors, captopril and enalapril, in patients with chronic renal failure results in regression of left ventricular mass index associated with a significant improvement in the diastolic function of the left ventricle without a demonstrable deterioration in left ventricular systolic performance.
Statins are widely prescribed and the risk of adverse drug reactions of lipid-lowering therapy is actively discussed, including muscle symptoms. This review synthesizes the knowledge about the clinical aspects of statin-associated muscle symptoms, which is important for the practitioner. Potential mechanisms of their development, risk factors, clinical manifestations, treatment and prevention are described. Timely detection the side effects of statins makes it possible to diagnose and eliminate, which is crucial for conducting lipid-lowering therapy for patients with atherosclerotic cardiovascular diseases. Management of statin-associated muscle symptoms requires altering (reduced dosages, use of another statin or alternative lipid-lowering drugs) or discontinuing the statin treatment.
Резюме В последние годы наблюдается отчетливое снижение частоты применения дигиталисных препаратов у больных с СН при синусовом ритме и фибрилляции предсердий. Результаты опубликованных исследований часто противоречат друг другу. Одни из них ставят под сомнение благоприятный эффект дигоксина у больных с СН, другие опровергают увеличение летальности и частоты госпитализаций, ассоциированных с применением дигоксина. В связи с этим мы сочли важным беспристрастно проанализировать эти сообщения и отразить современные взгляды на механизмы действия сердечных гликозидов, особенности фармакокинетики и возможности оптимизации дигиталисной терапии в кардиологической практике.
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