A new parameter quantifying depth variations in the cup floor significantly discriminated between groups of normal and glaucoma patients. This new parameter may contribute to a better understanding of the pathogenesis of the glaucomatous optic nerve damage in different types of glaucoma.
Glaucoma is the second leading cause of irreversible blindness in the world with a higher prevalence in those of African Descent (AD) and Hispanic Ethnicity (HE) than in those of European Descent (ED). The objective of this study was to investigate the pressure dependent biomechanical response of the lamina cribrosa (LC) in normal human donor tissues from these racioethnic backgrounds. Pressure inflation tests were performed on 24 human LCs (n=9 AD, n=6 ED, and n=9 HE) capturing the second harmonic generation (SHG) signal of collagen at 5, 15, 30, and 45 mmHg from an anterior view. A non-rigid image registration technique was utilized to determine the 3D displacement field in each LC from which 3D Green strains were calculated.
SUMMARY This is the first report of a ring-shaped, primary cyst of the iris pigment epithelium. The patient, a 28-year-old woman, presented with angle closure glaucoma. Ocular pressure was controlled medically, and the iris cyst was treated by argon laser photocoagulation. The derivation of the cyst, differential diagnosis, and mechanism of angle closure glaucoma are discussed.
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