Hassanloo A, Watson P, Finer Y, Friedman S. Retreatment efficacy of the Epiphany soft resin obturation system. International Endodontic Journal, 40, 633-643, 2007. Aim To assess the efficacy of retreatment of canals filled with the Epiphany System with and without solvent, with particular reference to the extent of canal enlargement during retreatment. Methodology Sixty roots with canals prepared to apical size 45 were embedded in resin blocks and sectioned vertically. Digital micrographs of canal walls were captured. Roots were re-assembled and filled with Epiphany/Resilon (experimental) or gutta-percha/AH Plus (control). After 8 weeks, canals were retreated to size 45 with or without chloroform, and the time recorded. Roots were split, imaged, re-assembled, retreated to size 55, split and imaged. Root-filling residue, traced at three canal levels, was expressed as percentage of canal surface. Results Residue percentage was greater (t-test, P < 0.01) in the experimental group than in the control. Most residue in all specimens was in the apical third (anova, P < 0.01). Chloroform and enlargement to size 55 decreased residue in both groups (t-test, P < 0.01). Retreatment time was longer in the experimental group (P < 0.05), and reduced by chloroform in both groups (P < 0.05). Conclusions The Epiphany System was retreatable with and without chloroform, with lesser efficacy than gutta-percha and AH Plus sealer.

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We investigated the effects of insulin (1-1,000 nM), insulin-like growth factor (IGF)-I, and IGF-II (3-100 nM each) alone or together with 10 nM dexamethasone (DEX) or 10 nM 1,25-dihydroxyvitamin D(3) (1,25[OH](2)D(3)) on proliferation and differentiation of adipocyte and osteoblast progenitors in bone cell populations derived from fetal rat calvaria. The effects on differentiation were evaluated by counting the number of bone or osteoid nodules and adipocyte colonies and the effects on proliferation, by measuring their size by image analysis. The types of cells studied were 1,25(OH)(2)D(3)- and DEX-responsive adipocyte progenitors and DEX-dependent and independent osteoprogenitors. Both IGF-I and IGF-II stimulated osteoprogenitor differentiation both alone and in the presence of DEX, while insulin stimulated osteoprogenitor differentiation only in the absence of DEX. Neither IGF-I/-II nor insulin affected proliferation of osteoprogenitors. Insulin had little effect on adipocyte differentiation by itself but strongly stimulated differentiation in the presence of either 1,25(OH)(2)D(3) or DEX, while IGF-II stimulated adipocyte differentiation in both the absence and presence of 1,25(OH)(2)D(3) or DEX. IGF-I by itself or in the presence of DEX strongly stimulated adipocyte cell differentiation but had little effect in the presence of 1,25(OH)(2)D(3). Our results demonstrate that insulin, IGF-II, and IGF-I have specific and different effects on the differentiation and proliferation of different groups of progenitor cells.