The present study screened riboflavin mimicking small molecules to determine their binding activity for the riboflavin binding protein. We performed thermodynamic and kinetic binding studies of these molecules using a combination of two analytical approaches; isothermal titration calorimetry and surface plasmon resonance spectroscopy. Screening of a biased set of non-riboflavin based small molecules by microcalorimetry led to the discovery of two known drug molecules, quinacrine and chloroquine, as favorable ligands for the riboflavin receptor with KD value of 264, and 2100 nM, respectively. We further demonstrated that quinacrine is a competitive ligand for the receptor as measured by surface plasmon resonance. Thus this study describes the identification of a novel class of dual acting riboflavin antagonists that target riboflavin receptor for cellular uptake and display multifunctional activities upon cellular entry.
Experimental results are presented on the charge, velocity, and angular distributions of intermediate mass fragments (IMFs) for the reaction Fe+Au at bombarding energies of 50 and 100 MeV/nucleon.Results are compared to the quantum molecular dynamics (QMD) model and a modified QMD which includes a Pauli potential and follows the subsequent statistical decay of excited reaction products. The more complete model gives a good representation of the data and suggests that the major source of IMFs at large angles is due to multifragmentation of the target residue.PACS number(s): 25.70.Mn
Diatomic potentials for krypton are computed and also probed experimentally. For a probe-laser wavelength near 811 nm, several strong dipole-dipole interactions produce purely-long-range potential wells in the singly excited manifold of (s + p) potentials and in the doubly excited manifold of (p + p) and (s + d) potentials. Evidence of resonant photoassociation into bound states of these potential wells is observed in the emission of ions and ultraviolet photons from a magneto-optically trapped krypton cloud.
A phoswich array consisting of 48 ..6.E-E elements with sufficient granularity (..6.9 = ±2.5 o) to handle high multiplicity events has been built and used in several experiments. The full angular coverage is a 35 o x 35 o square cross section of the 47r sphere. Unit charge resolution for Z < 10 and mass resolution for Z=l particles has been achieved with a ± 5% energy resolution.Experimental details and the performance of the array are presented and discussed.t
Cross sections, parallel and perpendicular momentum transfers, charge loss, and velocity systematics are presented for fission following reactions of Fe and Nb projectiles at 50-100 MeV/nucleon on targets of Ta, Au, and Th. Data are compared to simple models for peripheral heavy ion collisions. PACS number(s): 25.70. Jj, 25.70. -z, 25.85.Ca
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.