Background:Copper amine oxidases catalyze amine oxidation using copper and a quinone cofactor. Results: Halides bind axially to the copper center, preventing the reduced cofactor from adopting an on-copper conformation. Conclusion:The cofactor undergoes large conformational changes during the catalytic reaction that enable transitions between different types of chemistry. Significance: Molecular details of cofactor movement have been unveiled based on structural and kinetic evidence.

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