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Cardiovascular disease and cancer are the two leading causes of morbidity and mortality worldwide (Fuster and Voute, 2005). Over the last half century, radiation therapy (RT) has evolved to become one of the cornerstones of treatment for various types of cancers. It is estimated that more than 50% of patients with cancer are treated with radiotherapy (Yusuf et al., 2011). Radiotherapy is frequently used as a part of cancer treatment to achieve tumor control. Although, radiotherapy treatment has been widely used as an effective tool to kill tumor cells, it might produce harmful effects to surrounding healthy tissues (Sezen et al., 2008 and Ostrau et al., 2009). It is well known that ionizing radiations induce oxidative stress on target tissues, mainly through the generation of reactive oxygen species (ROS) resulting in imbalance of the pro-oxidant and antioxidant in the cells, attack diverse cellular macromolecules such as DNA, lipids and proteins, eventually inducing cell death (Boerma and Hauer-Jensen, 2011).

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